Background: Preeclampsia is a pregnancy-specific, multi-system disorder characterized by elevated blood pressure and proteinuria after 20 weeks of gestation. Its exact etiology remains unknown, and globally, it stands as a prominent cause of maternal and infant morbidity and mortality. This study aimed to assess the comparative demographic and clinical profile of preeclamptic and normal pregnant women in the third trimester. Methods: This case-control study took place in Bangabandhu Sheikh Mujib Medical University Hospital and Dhaka Medical College Hospital, Dhaka, Bangladesh, spanning from July 2011 to June 2012. The study enrolled 100 pregnant women, with 50 cases diagnosed with preeclampsia and 50 controls representing normal pregnant women. Data analysis was conducted using SPSS version 23.0. Results: The mean ages of cases (25.8 ± 4.4 years) and controls (27.1 ± 3.1 years) were similar (P=0.177). A predominant proportion of cases (74%) and controls (66%) belonged to a lower social class (P=0.383). BMI assessment showed no significant difference (P= 0.645). Most participants in both groups were preterm (P=0.235) and primigravida (P= 0.422). The case group exhibited significantly higher mean serum ferritin than the control group (P<0.001). Hemoglobin and hematocrit levels showed no significant differences (P=0.761 and P=0.231, respectively). Elevated serum ferritin (>20 ng/ml) was prevalent in 76% of cases and 44% of controls (P=0.001). The odds of elevated serum ferritin in preeclampsia were approximately 4 times higher than in normal pregnancies (95% CI=1.7–9.5). Variations in serum ferritin levels across gestational ages are illustrated. Conclusion: The study found no significant correlation between preeclamptic and normal pregnant women's demographic and clinical status in the third trimester, except for serum ferritin levels. Further research is needed to obtain a clearer understanding of these relationships.

Background: Medical treatment of abortion has been identified as safe and effective Method of evacuation of uterus and is more amenable to provision through primary care facilities, ever where providers may not have the skills to perform a surgical evacuation. Medical treatment of abortion care encompasses the management of various clinical conditions including incomplete abortion missed abortion, blighted ovum, as well as post-abortion contraception. Medical management of abortion generally involves misoprostol. Objective: To assess the role of medical treatment in abortion in pregnant women-an observational study. Methods: This is an observational study done at Uttara Adhunik Medical College Hospital, Dhaka, Bangladesh from July 2021 to July 2023. 101 patients fulfilling the inclusion criteria were enrolled. This is an attempt to study incomplete abortion after medical treatment of abortion and to observe the success read of this method of taking it among patients, with prescriptions or without it. Questionnaires were prepared and women were interviewed. Questions pertaining to women knowledge, attitude, perception and use of medicine for treatment of abortion, use of emergency contraception were asked. Study was carried out by using responses in the preform given. Results: This study was done in duration of two years and 101 patients fulfilling the inclusion criteria were enrolled. Women who had ectopic pregnancy, threatened abortion & excessive P/V bleeding were excluded. In our study, most of the women interviewed, were between 25-34 years of age (51.5%). Out of the 101 women, 99 women (98.01%) were married and 2 (1.99%) were unmarried. 76 women (75.2%) belonged to urban residence. 16 women (15.9%) were working women. 81 women (80.2%) were housewives. 4 (3.9%) interviewed were students. 41 women interviewed were illiterate (40.6%) while only 9 women (8.9%) were graduates. In our study, majority of women 76 (75.2%) had taken abortifacient or spontaneous abortion occur at <12 weeks of gestation. However, 05 (4.9%) women did not know about their gestational age. Main complication after taking medicine for abortion was moderate bleeding mentioned by 60 women (59.4%), incomplete abortion by 10 women (9.90%), Repeat prescription after 1 week 05 women (4.95%), pain by 27 women (26.7%) and need MVA or D&C by 07 women (6.93%). Among the 101 women who used misoprostol with known outcome, 90.09% had complete abortions, 10 (9.90%) had incomplete abortions. The rates of incomplete abortion and surgical intervention were not significantly different among the women with administration of misoprostol. Among blighted ovum after treatment, complete abortion 69.3% and 30.7% incomplete abortion. Conclusion: Medical treatment of abortion is safe and effective but complications can occur if not used in accordance. However, the awareness about medical treatment of abortion is increasing. It is therefore of utmost importance to increase the awareness about medical treatment of abortion not only among doctors but also among general population.

Background: Cervical cancer prevention strategies are evolving by integrating new screening modalities such as human papillomavirus (HPV) DNA testing and visual inspection with acetic acid (VIA). Colposcopy, as a diagnostic tool, plays a crucial role in the management of abnormal cytology smears, especially in developed countries. However, its utilization and efficacy in resource-limited settings like Bangladesh remain underexplored. Objective: This study aimed to assess the correlation between VIA positivity and colposcopic/histopathological findings in diagnosing precancerous cervical lesions among women in Bangladesh. Method: A cross-sectional study was conducted among 200 women aged 30-60 attending the Gynecology OPD of Dhaka Medical College and Hospital. VIA positivity was determined, and all positive cases underwent colposcopic evaluation. Histopathological examination was performed for tissue samples obtained during colposcopy. Result: Among the participants, 21% were VIA-positive. Colposcopic evaluation revealed inflammation (26.2%), CIN I (38.1%), CIN II (11.1%), CIN III (9.5%), and invasive carcinoma (9.5%). Histopathology findings included inflammation (28.6%), CIN I (40.5%), CIN II (7.1%), and invasive carcinoma (16.7%). True positive and false positive cases were identified, with percentages calculated accordingly. Conclusion: Detailed colposcopic evaluation with guided biopsy is crucial for detecting pre-invasive and early cervical cancer. Integrating colposcopy into screening programs in Bangladesh could significantly reduce morbidity and mortality among young women.

Background: Pregnant women with pre-existing diabetes face an elevated risk of congenital anomalies in their offspring. However, research on the pattern of congenital anomalies and its correlation with blood sugar control in pre-gestational diabetic mothers is limited, especially in our country's context. This study investigated the association between elevated HbA1c levels and congenital anomalies in diabetes-related pregnancies. Objective: To assess whether raised HbA1c levels were linked to an increased incidence of congenitally deformed fetal outcomes in pregnancies affected by diabetes. Method: This cross-sectional study was conducted from August 2018 to September 2019 at the Department of Obstetrics and Gynaecology, DMCH. Women with pre-gestational diabetes were sequentially enrolled if they provided informed consent. Data, including HbA1c levels and anomaly scans, were collected at 18-24 weeks of gestation. Participants were divided into two groups based on HbA1c levels: Group-1 (elevated HbA1c) and Group-2 (normal HbA1c). Statistical analysis was performed using SPSS 22, with significance at p<0.05. Result: The mean ages of Group 1 and Group 2 were 31.60±2.89 & 30.51±2.99 (SD) years. Both groups were similar concerning age, residence, education, occupation, economic status, and BMI (p>0.05 in all factors). Mean HbA1C (%) of Group-1 and Group-2 were 8.57±2.22 & 6.18±0.20 (p<0.001), respectively. Congenital anomalies were more frequent in Group 1 (15.6 vs 2.2; p<0.05), and it is associated with high blood sugar levels (p<0.001) and with a previous history of anomalous babies in preceding pregnancies. Conclusion: Elevated HbA1c levels are associated with an increased incidence of congenital anomalies in pregnancies complicated by diabetes. This underscores the importance of strict glycemic control in pregnant women with pre-gestational diabetes to mitigate the risk of adverse fetal outcomes. Further, population-based studies are desired to validate these findings and inform clinical management strategies.

Background: Cervical cancer is the most frequent cancer in women worldwide. With appropriate screening, the condition can be prevented and treated. Colposcopy is a useful tool in the diagnosis and management of precancerous cervical lesions following primary screening. The gold standard for identifying precancerous lesions is histopathology. Objective: The aim of this study is to evaluate the diagnostic performance between colposcopy findings and histopathology reports Methods: The cross-sectional observational study was conducted in the Department of Colposcopy Clinic of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from July 2022 to June 2023. A total of 62 subjects were included in the study. The questionnaire was pretested, corrected and finalized. Data were collected by face-to-face interview and analyzed by appropriate computer based programmed software Statistical Package for the Social Sciences (SPSS), version 24. Results: In this study, the mean age was found to be 36.8±11.9 years, with a range from 20 to >51 years maximum 44 (71.0%) of the patients were within the age group of 20 - 40 years. The majority 37 (59.7%) of patients completed SSC and most of the patients 56 (90.3%) were housewives. Most of the patients 59 (95.2%) were Muslims and about 32 (51.6%) came from middle-income families. About 25 (40.3%) patients were married between the ages of 15-17 years. About 25 (40.3%) were between 16-18 years during their first delivery and about 26 (41.9%) had 3-4 children and 21 (33.9%) had more than 4 children. Most of the patients 43(69.4%) had history of received OCP. Regarding colposcopic diagnosis, 12.9% (n=8) were normal, 69.4% (n=43) were CIN I, 9.7% (n=6) were CIN II and 8.1% (n=5) were CIN III and 30.6% (n=19) chronic cervicitis, 46.8% (n=29) CIN I, 6.5% (n=4) CIN II, 6.5% (n=4) CIN III, 4.8% (n=3) carcinoma in situ and 4.8% (n=3) were invasive squamous cell carcinoma by the histopathological diagnosis. Conclusion: Colposcopy had a rather high diagnostic accuracy for histopathologically verified precancerous cervical lesions. Even if the results of the screening tests are normal, patients who report with postcoital and postmenopausal bleeding should have colposcopies and biopsies. Colposcopy also has a high sensitivity, therefore it is simple to use the "see and treat" approach to lower dropout rates.

Background: Dysmenorrhea is a common symptom secondary to various gynecological disorders, but it is also represented in most women as a primary form of disease. Pain associated with dysmenorrhea is caused by hypersecretion of prostaglandins and an increased uterine contractility. The primary dysmenorrhea is quite frequent in young women and remains with a good prognosis, even though it is associated with low quality of life. Objectives: The aim of this study is to evaluate of the efficacy and safety of dienogest in the treatment of primary dysmenorrhea: a study in a district-level hospital in Bangladesh. Methods: The cross-sectional observational study was conducted in the Department of Gynae and Obs, Naogaon Sadar Hospital from July 2022 to June 2023. A total of 100 subjects who received DNG (1 mg/day, orally) were included in the study. Data were collected by face-to-face interview and analyzed by appropriate computer based programmed software Statistical Package for the Social Sciences (SPSS), version 24. Results: In this study, most of the patients 43% lies between 21 years to 25 years and body weight of 24% patients were between 51 to 55 kg. In this study, most of the patients 41% body mass index were 18.5 – 24.9 kg/m2. Most of the patients’ clinical symptoms were cramping pain in the lower abdomen (89%), low back pain (86%), pain spreading down to the leg (73%), fatigue (64%). About (56%) adverse effects were body weight gain and irregular uterine bleeding occurred in 35 of 100 cases (35%). Conclusion: Primary dysmenorrhea is one of the most common illnesses in women of childbearing age. When severe, it may interfere with the activities of daily living and may lead to school and work absenteeism. Primary dysmenorrhea is also one of the most underdiagnosed diseases, so clinicians should suspect the diagnosis in a timely manner and provide appropriate treatment.

Introduction: Maternal mortality is a tragedy and constitutes a triple scourge. It is dramatic for the family (which falls apart after the death of the woman), unacceptable for the medical profession (since there are obstetric means to save mothers), and unacceptable for society (dying while giving birth). However, it seems to increase every year in the city of Kinshasa, due to several factors including the lack of easy access to quality care and childbirth services. The main objective for this study was to investigate the trend in maternal mortality at the Kintambo maternity ward from 2014-2017 including the relative contribution of risk factors linked to the lack of easy access to care and services quality delivery. Methods: This is an observational case-control study among pregnant women who followed ANC or not at the Kintambo maternity ward, but who all gave birth from January 2014 until December 2017. The use of the survey method, based on the analysis of registers, with a data collection sheet (check list) which was used for the collection of data, proved essential to bring this to fruition research. The sample size was exhaustive for cases (63 cases) and 63 controls. Results: Trend in female mortality between 2014-2017 at the Kitambo maternity ward in the city of Kinshasa has been decreasing, i.e. 22 cases in 2014, 17 cases in 2015, 14 cases in 2016 and 10 cases in 2017. It was observed that the variables show a very significant difference in relation to the factors which are the age of the pregnant woman, attendance at the CPN, delivery in the same center, the number of doctors in the delivery room and the distance between the residence and the center with an added value (P) less than 0.008; In comparison to pregnant women who die or not during childbirth and the factors in relation to their Chi-square, the age of gestation has a higher. Conclusion: Reducing this mortality requires strengthening the capacities of midwives /midwives in the care of pregnant women from conception to delivery and in the postpartum period , providing maternity wards with all the assets for good operationalization in the farthest corners of the city center , raising awareness among pregnant women of the importance of attending the CPN, ensuring good monitoring of the pregnant woman during her pregnancy and during childbirth, and for women to be always accompanied by their husbands during the CPN in order to help them internalize certain notions.

Introduction: Domestic violence can take several forms: physical, sexual, psychological or economic. It occurs between partners or former partners in an intimate relationship, regardless of whether the perpetrator shares or has shared the same home as the victim. The aim was to understand the daily experience of married women in the city and province of Kinshasa, whether they experience violence within couples. Methods: This study falls into the field of public health, more precisely it deals with the protection of women's rights. It is a qualitative study, approached in its phenomenological approach. The target population is made up of married women attending the Matete New Alliance Hospital Center whose sample size is 11. It was determined after collecting the data, the redundancy of which was observed at the 10th head of household. Results: the marriage of a violent partner represents a stumbling block for women and an obstacle to women's emancipation; In their union sexual violence, physical violence or torture, deprivation of financial means (financial violence); They encountered consequences such as gastritis, tension disorders, neurosis. As for coping strategies in the face of violence: the women interviewed resort to spiritual support by relying on God, dialogue with their partner, entertainment and asking friends for advice. As for expectations, women want the Congolese State to create schools for the re-education of husbands and for educators (parents and churches) to give advice to young people before marriage. Conclusion: It is important for the Congolese State, families, schools and churches to establish/reinforce the notion of initiating men to good behavior in marriage.

Background: Pre-eclampsia is a multisystem disorder of pregnancy characterized by Hypertension and proteinuria. It is a common pregnancy related disorder that originates in the placenta and causes variable maternal and fetal problems. Objective: To find out the feto-maternal outcome of severe pre-eclamptic patient. Methodology: It was a cross-sectional study among the pregnant woman who were admitted with severe pre-eclampsia in labour and in antenatal ward in the hospital during the study period in Department of Gynaecology, Dhaka Medical College and Hospital, Dhaka from July 2015 to January 2016. A total of 50 pregnant women with severe pre-eclampsia were included in the study. After detailed history, clinical examination, blood pressure measurement and bedside urinary protein levels, patients were diagnosed as severe pre-eclampsia. The data were analyzed by SPSS. Results: Commonest age group of the patients suffering from severe pre-eclampsia was found to be ranging from 15-35 years of age and the mean age was 26 years. Majority of the study, patients were primiparous (56%) coming from rural areas (56%). Literacy has a great impact on the incidence of pre-eclampsia which was reflected from the study of educational status. The study revealed that 40% of patients were under secondary school level and only 28% of them were graduates or above HSC. Data was collected regarding their occupation, which showed 80% of them were house-wives and 12% were day laborer. Most of them gave a positive family history of hypertension and 32% of them gave no relevant history. Incidence of antenatal care was assessed which showed majority (60%) were on irregular antenatal care which again contributes to the progress of severity of the disease. 92% of severe pre-eclamptic patients were found to be present in last trimester. Blood pressure levels were assessed and 80% of patients had systolic pressure more than 160 mmHg and 76% had diastolic pressure more than 110 mmHg. Among the various symptoms of severe pre-eclampsia most common symptom were Oedema (76%), headache (40%), epigastric pain (12%) and Insomnia (32%). Study of blood biochemistry levels showed high levels of uric acid (72%) and raised serum creatinine levels (26%). Caesarean section rate was found to be extremely high. 72% of the patients underwent caesarean section and rest was delivered vaginally. Overall neonatal outcome was- healthy babies 40%, premature 20%, IUGR 20% and IUD was 8%. Most of them had average birth weight (56%). And overall maternal outcome was Eclampsia 4%, HELLP Syndrome 4%, Abruptio placenta 4%, Renal Insufficiency2% and maternal death 2%. Conclusion: The incidence of morbidity and mortality related to sever pre-eclampsia are remarkably higher in developing countries like Bangladesh. Therefore, measures should be taken to control this deadly condition through Behavioral Change Communication (BCC) regarding antenatal care, danger signs, delivery plan etc. involving public and private sector.