Background: Male infertility is a significant yet under-reported public health concern. It affects 30% of couples who regularly engage in unprotected sexual activity. In Nigeria, the male partner is sometimes unwilling to have a fertility evaluation, which results in the underreporting of male infertility. The female partner is frequently held responsible for infertility. Hyperprolactinaemia has been identified as a reversible cause of male infertility, which is amenable to treatment, but studies to evaluate the concept are sparse. Aim: To determine if there is an association between high prolactin levels and abnormal seminal fluid analysis parameters. Methods: The study is a cross-sectional analytical study involving male partners of infertile couples. Two hundred and thirty-three (233) patients that met the inclusion criteria and gave informed consent were enrolled on the study at the Human Reproduction and Research Program Unit (HRRP) of the University of Benin Teaching Hospital, Benin-city, Nigeria. A detailed history was taken, and a physical examination was done for all subjects. Seminal fluid analysis was done for all subjects, and blood was also collected for serum prolactin assay. Information was obtained from sociodemographic data and medical history. Data obtained using interviewer-administered questionnaires were analyzed with SPSS Package version 20.0. Results: The study included 233 patients, with a mean age of 40.77.1 and a majority (57.7%) of the subjects with aberrant SFA between the ages of 40 and 49. Participants with normal and abnormal SFA had hyperprolactinemia at 4.3% and 14.2%, respectively. There was a significant negative correlation between prolactin level, motility (r=-0.010, p=0.001), morphology (r=-0.077, p=0.001) and sperm count (r=-0.082, p=0.003). Obesity, alcohol consumption and smoking were significant predictors of abnormal sperm parameters (p=0.011, p=0.001, and p=0.001, respectively). Conclusion: This study indicated a relationship between hyperprolactinaemia, sperm count, motility, and morphology, which suggests that increased prolactin may negatively affect semen quality if left untreated.

Introduction: The estimation of fetal weight during pregnancy has a significant impact on the survival of newborns and some immediate and late sequelae of the life of newborns. Estimation of fetal weight also plays a paramount role in determining time, mode, and place of delivery. There are many methods to estimate fetal weight like the palpation method, fundal height measurement, and radio frequency volume reduction. Johnson's method is one of the clinical methods that require no expense and is easier to estimate the precise birth weight and fetal weight. This study aimed to analyze the accuracy of the Johnsons formula for estimating fetal weight compared to actual birth weight. Methods: This cross-sectional prospective study took place in the Gynecology and Obstetrics Department of Rangpur Medical College Hospital, Rangpur, between May 2015 to October 2015, six (06) months after approval. The sample size was 600 as per inclusion criteria. Data were collected through face-to-face interviews with the women by using a pre- design questionnaire after proper counseling and informed written consent. The purposive sampling method was used in the study. Data processing was consisting of registration schedule, editing, computerization, preparation of dummy table, analyzing & matching of data. Statistical analysis was carried out by using the Statistical Package for Social Sciences version 16.0 for Windows. The mean values were calculated for continuous variables. The quantitative observations were indicated by frequencies and percentages. Paired t-test was used for continuous variables. Pearson's correlation coefficients were used to test the relationship between the groups. P values <0.05 was considered statistically significant. Result: The mean age was found 24.5±5.1 years with a range from 18 to 38 years. The mean symphysio fundal height was found 32.4±2.0 cm with a range from 28 to 36 cm. The mean estimated fetal weight was found 3205.2±287.9 grams with a range from 2635 to 3875 grams. The mean actual birth weight after delivery was found 3019.0±359.0 grams with a range from 2200 to 3800 grams. The difference was statistically significant (p<0.05) between the two groups. A positive significant correlation (r=0.929; p=0.001) was found between actual birth weight and estimated fetal weight by Johnson's formula. A positive significant correlation (r=0.517; p=0.001) was found between actual birth weight and symphysio fundal height. A positive significant correlation (r=0.129; p=0.002) was also found between the actual birth weight neonate and the BMI of the mother. Conclusion: Antenatal and intranatal fetal weight can be estimated with reasonable accuracy, clinically using Johnson's formula. Ultrasound is not available in remote areas where Johnson's formula is easy and simple to calculate and can be included in the training program of medical and paramedical staff and birth attendants.

Introduction: Oligohydramnios is a pregnancy disorder characterized by a shortage of amniotic fluid volume. It is a rather common obstetric complication that has severe effects on the health of both the mother and the fetus. Early identification is essential for prompt diagnosis and therapy because the clinical appearance of oligohydramnios can vary greatly. This study aimed to investigate the various modes of presentation of oligohydramnios in patients admitted to Bangabandhu Sheikh Mujib Medical University (BSMMU), a tertiary care hospital in Bangladesh. Methods: This prospective observational study was carried out on the admitted patients at the Department of Gynaecology and Obstetrics in Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from February to July 2008 (6 months). A total of fifty women (N=50) having Oligohydramnios in pregnancy were included in the study. Completed data forms were reviewed, edited, and processed for computer data entry. The data analysis was performed using Statistical Package for Social Sciences (SPSS) Version 25.0.The ethical clearance of this study was obtained from the Institutional Review Board (IRB) of BSMMU, Dhaka, Bangladesh. Results: The mean age of the mothers was 25.8 years and two-fifths of the mothers (20, 40.0%) belonged to 21-25 years old. Twenty-three mothers (23, 46.0%) were nulliparous. Of fifty mothers (N=50), eighteen (18, 36.0%) had borderline oligohydramnios and thirty-two (32, 64.0%) had severe oligohydramnios. Normal CTG tracing was found in eighteen patients (18, 36.0%) and abnormal CTG was found in thirty-two patients (32, 64%) (p < 0.01) which was statistically significant. Among the alive babies after initial resuscitation, twenty-three babies (23, 50.0%) were required to get admitted. Twelve admitted babies (12,52.2%) stayed in the neonatal ward for <7 days and among them one baby (1,8.3%) died, nine babies (9,39.1%) were treated for 7—21 days, among them two babies (2,22.2%) could not survive and two babies were treated for more than 21 days but could not survive. Conclusion: According to the findings, severe oligohydramnios was linked to a higher risk of cesarean delivery, higher APGAR ratings, and probable issues that would necessitate neonatal admission and care.

Annulo-ectasitic disease is a group of disorders with similar phenotypic features, combining aneurysm of the aortic duct and dilatation of the aortic annulus. Its incidence is estimated at 4.5 cases per 100,000. It is the 13th leading cause of death in Western countries. Aneurysms of the ascending aorta are divided into two distinct entities according to etiology and surgical management. Pregnancy and peri-partum are two situations where the risk of aortic dissection is higher, with a more rapid progression of aortic diameters. This risk is directly related to the diameter of the aorta at the beginning of pregnancy, compliance with beta-blocker treatment, and the need for concerted cardiological and obstetric monitoring as soon as the desire for pregnancy is expressed and up to the 2nd month of the peripartum period. The aim of this review is to illustrate, through 02 clinical situations, the difficulties in managing parturient patients suffering from the different types of annuloectasitic disease of the aorta.

Background: It has been revealed that low serum magnesium (Mg) is often associated with insulin Resistance (IR), cardiovascular problems, diabetes mellitus, and hypertension. Patients with polycystic ovary syndrome (PCOS) are known to have a high incidence of insulin resistance. Objective: To assess the effects of magnesium supplementation on insulin resistance in polycystic ovary syndrome. Methods: This randomized controlled study was conducted in the Department of Reproductive Endocrinology and Infertility, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, from January 2021 to December 2021. A total of 74 women diagnosed of infertility with PCOS were included in this study. Eligible women who gave their informed consent were allocated into either group A: (Magnesium oxide) or group B (placebo) on the basis of a computerized generated table system allocated into two groups 37 patients (group-A) and 37 patients (group -B). Group A received magnesium oxide & group B received a placebo for 12 weeks. After 12 weeks of treatment, both groups were advised to repeat biochemical assay for fasting glucose, fasting insulin, HOMA-IR, serum testosterone & serum lipid profile at the follow-up visit. Results: Magnesium supplementation for 12 weeks among women with PCOS had favorable effects on waist circumference (changes from baseline in the intervention group: -0.76±3.1 vs. -1.7±1.8 cm in the placebo group) and BMI (-2.13±0.98 vs. -0.32±0.52 kg/m2) compared with the placebo group. Magnesium oxide led to a significant reduction in HOMA-IR (-1.49±0.95 vs. 0.09± 0.29) compared with placebo. Serum triglycerides was significantly decreased (-36.7±53.5 vs. 0.1±17.9 mg/d) in the magnesium group than placebo. HDL level was significantly increased in the magnesium group (2.3±5.9 mg/dl), while HDL level was decreased in the placebo group (-1.7±2.7 mg/dl). Significant mean change of total testosterone in magnesium group (0.43±0.35 ng/dL) than placebo group (-0.01±0.05 ng/dL). However, total cholesterol and LDL were also decreased in the magnesium group than in the placebo group, but the difference was not statistically significant (p>0.05) compared between the two groups. Conclusion: The present study provides evidence showing that magnesium supplementation resulted in reduced WC, BMI, HOMA-IR, total cholesterol, triglyceride, LDL, and testosterone levels in women with PCOS. Also, magnesium supplementation might increase serum HDL levels. Though there was a significantly increased pregnancy rate of magnesium supplementation than in a placebo group.

Background: Polycystic ovary syndrome (PCOS) is a common disorder in women of reproductive age closely related to insulin resistance, obesity, dyslipidaemia and long term diseases including diabetes and cardiovascular disease. The management of PCOS may be challenging on account of the comorbidities associated with the disease. Objective: The objective of the study was to evaluate the effect of Levocarnitine supplementation on physical and biochemical parameters in polycystic ovary syndrome. Methods: This randomized controlled study was conducted in the Department of Reproductive Endocrinology and Infertility, Bangabandhu Sheikh Mujib Medical University, Dhaka from January 2021 to December 2021. Total 78 diagnosed cases of PCOS were selected for medication and were included in this study. Eligible women who gave their informed consent were allocated into either Group A (Levocarnitine) or Group B (Placebo) on the basis of computer generated table. Group A received Levocarnitine and Group B received Placebo for 12 weeks. Then pretreatment and post treatment physical parameters including BMI, waist circumference and biochemical parameters including cholesterol, triglyceride, LDL, HDL, fasting plasma glucose, fasting insulin, HOMA-IR were assessed. Results: Treatment with levocarnitine significantly reduced BMI (-6.00±0.00 vs -0.45±0.07) waist circumference (-4.88±2.85 vs -0.77±0.30) compared with the placebo. In Levocarnitine group, total cholesterol (-38.15±7.33 vs -0.79±27.00 mg/dl), serum triglycerides (-60.00±53.33 vs. -0.33±9.59 mg/d) and LDL (-23.49±1.81 vs. -0.41±0.07 mg/dl) were significantly reduced and HDL level was significantly increased (4.23±1.62 vs 0.41±0.49 mg/dl) compared with the placebo group. Moreover, compared with the placebo, levocarnitine led to a significant reduction of fasting plasma glucose, fasting insulin and HOMA-IR (-0.49±0.95 vs. 0.09± 0.29). Conclusion: In conclusion, levocarnitine administration led to an improvement in physical parameters including BMI, waist circumference as well as biochemical factors including cholesterol, triglyceride, LDL, HDL. Insulin resistance was significantly reduced in post treatment patients of Levocarnitine. In contrast, although physical and biochemical parameters improved in the placebo group, the change was not significant.

Female genital mutilation covers all interventions including the partial or total removal of the female external genitalia or any other lesion of the female genitalia that are carried out for non-medical reasons. They can be serious due to the occurrence of complications and sequelae. Our observation was a case of sequellar vaginal stenosisaftergenital mutilation performed 15 years ago. The discovery of the stenosis was linked to a difficulty in being able to consum mate his marriage. The diagnosis of stage III vaginal stenosis was suggested and disinfibulation associated with vaginal dilation was performed.

Choice of delivery is as important as getting pregnant for the first time. Delivery could be spontaneous vagina delivery (SVD) or caesarean section (CS). African culture believes in spontaneous vagina delivery which it cannot be compromised. This study is to evaluate the Preferred Method of Delivery Amongst Women of Reproductive Age in South-South, Nigeria. This was a cross-sectional study involving 260 females who were within the age of 18 to 45 years. A well-structured questionnaire was administered to participants. Each participant had one questionnaire to fill appropriately and independently after instructions were given to them by the researchers. The study lasted for a period of 6 months. The study revealed that 51.4% of the participants have tertiary level of education, 43.8% had secondary level and 4.8% had primary level of education. 69.5% of the participants were married, 24.8% were single, 1.9% were cohabiting and 3.8% are widow.96.0% are Christian, 3.0% were Moslem and 1.0% were African Traditional Believers. 72.4% of the participants were pregnant and 27.6% were not pregnant. 97.1% of the participants have preferred method of delivery and 77.9% preferred spontaneous vaginal delivery and 22.1% preferred cesarean section. Also, the study revealed the reason why the most of the participants preferred spontaneous vaginal delivery as culture (13.6%), pride (11.4%), religion (20. 8%), cost (32.8%) and fear (16.8%).