A simple, precise and gradient RP- HPLC method has been developed and validated for Aciclovir raw and in tablet formulation. The proposed method was validated to obtain official requirements including accuracy, linearity, precision, selectivity and stability. The estimation was developed on C(18) column reversed-phase using the mobile phase composition as Phosphate buffer: methanol in the ratio (60:40 %. v/v). 1ml /minute was the flow rate and the maximum absorption were observed at 290 nm using Shimadzu SPD-20A Prominence UV-Vis detector. Aciclovir showed a precise and good linearity, the concentration range was 5-25 μg/mL. The RP-HPLC, assay showed the highest purity ranging 99.59 to 100.97% for Acyclovir tablet formulation. 100.19 % was the mean percentage purity. The Aciclovir retention time was found to be 3.01 minutes. The method accuracy was showed by statistical analysis.

Grain starch in general has wide array of applications in industry, food preparation, paper surface coating and textiles. Many of the important functional properties of starch including the emulsion capacity, water and oil absorption, least gelation concentration and foaming capacity can be substantially improved from physical and chemical modifications. In this review, current and advances in grain starch modification technology was examined and the functional properties compared with the unmodified sample. Chemical modifications such as crosslinking starch granules with variety of cross-linkers such as citric acid improved the functional properties of acha starch significantly. The least gelation concentration (LGC) increased from 6% to 8% and the pasting viscosity also decreased to 25Cp Other chemical modification techniques examined include oxidation and acid treatment or mild hydrolysis. Several starch oxidizing agents were reviewed and the effect of sodium hypochlorite (3% active chlorine) on acha starch was compared to the native starch. Oxidation further reduced the pasting viscosity of native sample from 30Cp to 20Cp whilst the least gelation concentration was also reduced to 6%. Acid treatment affected the pasting viscosity of acha starch substantially (15Cp) whilst the LGC increased to 14%. The scanning electron microscopy (SEM) of modified samples showed effects on starch granule morphology

The present study was to extract the plant material of medicinal plant Melia azedarach, with different solvents (methanol, chloroform, ethyl-acetate and hexane) and isolate various novel compounds. The isolated compounds were identified by spectroscopic techniques.

In the present investigation the chemical effect on colour fastness of Phyllanthus muellerianus dyed wool was studied. Samples were assessed in terms of the colour fading to spotting with dilute hydrochloric acid, with 56% acetic acid, steeping for two minutes at room temperature in 28% ammonium hydroxide without rinsing, exposed to concentrated ammonia fume for 24 hours and spotting with 10% sodium carbonate and calcium hydroxide respectively. Contact with dilute hydrochloric acid brings about significant changes in the color and fastness properties of natural dyed wool yarn. The colours however, remain stable after exposure or contact with alkalis and 56% acetic acid. It can be concluded that Phyllanthus muellerianus dyed wool fabric have good colour fastness to perspiration and except with mineral acids.

This work is aimed at examining the effect of heavy metal concentration on surface water quality. This study was concentrated on the lower Niger River from Illah through Asaba/Onitsha to Okpai (Lat 6o 25' to Lat 5o 40' N and longitude 6o 37' to 6o 47' E). The data collected from water and were analyzed for the heavy metals (Zn, Cu, Pb, Cd, Ni, Fe, Mn and Co) using urican 929 Atomic Absorption Spectrophotometer. The results showed that Turbidity, BOD, TSS, hydrocarbon, coliform, magnesium and iron concentrations in the sampled settlement did not meet the WHO (2010) threshold for drinking water quality. The following conclusions were reached; the Niger River water must be treated before drinking, to remove or reduce the amount of non-essential or essential heavy metal and eating of fish species that have bio-accumulated heavy metals above the WHO limits for consumption must be prohibited or discouraged. Also, further studies should be carried out to monitor the heavy metal concentration in the lower Niger River and to identify the point sources of entry; and various contributors to the contamination of the River Niger. Heavy metals have however been grouped into two categories – Essential and Non-Essential. Zinc, Iron, Manganese, Copper and Cobalt are essential and beneficial elements but become toxic when their concentrations exceed those required for normal life Lead, Arsenic, Beryllium, and Mercury are non-essential and are not required in biological systems because they are toxic. The following recommendations were made; frequent environmental monitoring (at least twice a year) must be conducted to know levels of heavy metals contamination especially of the aquatic systems; Education of the neighbouring populace on protection of the environment through various technical programmes may very useful; The Niger River water must be treated before drinking, to remove or reduce the amount of non-essential or essential heavy metal such as Cr and Fe; The eating of fish species that have bio accumulated heavy metals above the WHO limits for consumption must be prohibited or discouraged; Further studies should be carried out to monitor the heavy metal concentration in the lower Niger river and to identify the point sources of entry; but, the result of this study should form the baseline data for the assessment of the various contributors to the contamination or otherwise of the River Niger. Thus, the pollution trends in the future can easily be monitored.