Background: Several epidemiological studies identify hyperuricemia is an independent risk factor for the development of cardiovascular disease and renal disease, particularly patients with hypertension or congestive heart failure and in women. In the present study to investigate the level of serum uric acid in Type 2 diabetes mellitus and pre-diabetics in south Indian population. Methods: Uric acid level was measured by Uricase-PAP methodology in patients with Diabetes (n=50)/Pre diabetes (n=50). Using Chi Square test, uric acid levels in the above two groups were compared based on age, sex and other factors which can affect uric acid level. Results: The mean serum uric acid level was lower in type 2 Diabetes Mellitus patients compared with Pre-diabetic patients. P value comparing type2 diabetes mellitus and pre-diabetes was < 0.001. Conclusion: The serum uric acid level being higher in pre-diabetes than diabetes mellitus may serve as a potential inexpensive biomarker of deterioration of glucose metabolism.

Background & objectives: Polycystic ovary syndrome (PCOS) is the most common disorder of ovarian pathology in women of reproductive age group Insulin resistance and hyperinsulinemia may play an important role in pathophysiology of PCOS. To estimate fasting plasma glucose, plasma insulin levels, insulin resistance and lipid profile in obese and non obese female infertile women with PCOS. To study the association between insulin resistance, lipid profile and obesity in female infertility in PCOS. Methods: 30 obese infertile women diagnosed by ultrasonogram as PCOS and with a BMI> 30Kg/m2attending Gynecology OPD at Narayana medical college and hospital were taken as cases. 30 age matched non obese infertile women with a BMI<30Kg/ m2 were taken as controls. Results: In our study the fasting glucose, fasting plasma insulin values and insulin resistance was significantly elevated among cases when compared to controls (P value <0.001). The Mean ± S.D values of LDL cholesterol were elevated in cases when compared to controls (P value <0.001). Interpretation & conclusions: This clearly shows the importance of screening for dyslipidemia and insulin resistance in Indian Women with PCOS. Hence periodic monitoring of lipid profile and B.P specially for obese PCOS patients may be advised.

In India it has been estimated that about 42 million people suffer from thyroid diseases. The prevalence of Thyroid gland disorders depend on age, sex, ethnic and geographical factors, especially on intake of iodine. Several studies have been already assessed the knowledge regarding thyroid gland among general population with or without thyroid disorder. However there is paucity of information about the thyroid knowledge among school students. Hence we conducted a study to assess the knowledge and awareness of thyroid and its disorder among students of rural area. An Observational Cross sectional study was conducted at Adichunchanagiri residential school, using random sampling, 50 students of age group 13-17 Yrs, who agreed to give the written informed consent have been considered as study-population and those who were not willing to participate in the study were excluded from the study. In the present study, students had an average knowledge about thyroid gland position and its importance. About 44% of the study population gave correct answer about the location of the thyroid gland and 54% gave correct answer about the importance of the thyroid gland in the body. With respect to thyroid gland function, study participants had very poor knowledge. 46% of the study population believe that thyroid gland function is only to regulate the body temperature. Increasing awareness of the thyroid as well as the common conditions that impact it is the first step in achieving better health for all. Our study findings reveal that the study population had an average knowledge regarding thyroid and its associated disorders. Furthermore, information about thyroid gland, its function and its disorders should be included in the curriculum of schools, colleges, and universities.

Background and Objectives: Diabetic nephropathy (DN), a common microvascular complication in diabetic patients, is characterized by gradually increasing urinary albumin excretion (UAE), and affects 20-40% of Type 2 Diabetes mellitus (DM) patients in India. The defective insulin action in the metabolism of lipoproteins leads to lipid abnormalities as well as glycation of lipoproteins cause abnormalities in the lipoprotein metabolism in Type 2 DM patients. Dyslipidemia causes glomerular injury which will lead to progression of proteinuria. Methods: 100 Type 2 Diabetic patients with not less than 10 years duration of diabetes were selected and divided in three groups; Normoalbuminuric (n=42), Microalbuminuric (n=41) and Macroalbuminuric (n=17). Lipid profile, HbA1c, S. Creatinine and Urinary Albumin Excretion (UAE) were measured and data analysis was performed. Result: Total Cholesterol (TC), Triglyceride (TG) and LDL-C levels were not significantly associated with increase in proteinuria. HDL-C levels and TG/HDL ratio were significantly associated with different stages of proteinuria. Conclusion: HDL–C levels and TG/HDL ratio can be considered an excellent tool and approach for estimating risk of development of overt proteinuria among Type 2 diabetes patients.

Objective of The Study: To assess C-peptide levels in Cord Blood of Infants born to Diabetic Mothers (GDM and type 2 DM mothers) and to find it’s correlation with the anthropometric measures of the new born. Materials and Methods: The study sample comprised 40 babies born to GDM mothers and 20 babies born to type 2 DM mothers. Controls consist of 30 babies born to non-diabetic mothers .Instituitional ethics committee approval was obtained. Anthropometric measures of the newborn including gestational age, birth weight, ponderal index, length of the babies and head circumference were measured. 10 ml of Cord blood was collected and cord serum was separated and stored at -200C until further analysis. C-peptide levels in the cord serum was measured by ELISA. Result: Significant increase was observed in the serum C-peptide levels in infants born to GDM and type 2 DM mothers. Birthweight, head circumference and other anthropometric measures were also found to be significantly increased in the infants of diabetic mothers and they showed a strong correlation with C-peptide levels. Conclusion: When the mother has type 2 diabetes / gestational diabetes mellitus (GDM), fetal hyperinsulinemia is common despite treatment of disease. This effect is more pronounced in those women with Type 2 DM. This maternal diabetic environment could be a contributing factor for the infants to develop obesity and abnormal glucose tolerance later in life. Therapeutic targets should be aimed at controlling the fetal hyperinsulinemia of GDM which could prevent the development of diabetes in the future.

The Malaysian medicinal plant, Water Apple’ (Syzygium Aqueum) can provide bioactive compounds that help to support people suffering from many diseases. The present study is undertaken to investigate the phytochemicals and invitro antioxidant activities from extract of Water Apple fruits. Determination of phytochemicals and invitro anti-oxidative capacity, established assay method 2, 2 - diphenyl – 1- picryl hydroxyl (DPPH) radical assay, nitric oxide and superoxide anion scavenging activity assays were used with reference to standard antioxidants ascorbic acid and butyl hydroxyl anisole (BHA).The percentage inhibition of radical scavenging activity increased with increase in concentrations of extract and when compared with standard antioxidants. The results show that the extract of fruits of Water Apple possesses significant antioxidant activity when compared to standard antioxidants. These findings provide a strong rationale to establish Water Apple fruits capability as an anti oxidant capacity. However, in-vivo antioxidant activity and mechanism of action is needed to be further studied.

We investigated the effect of vanadium citrate in the amounts of 0.125, 0.5 and 2.0 μg/ml of water on the indicators of lipid metabolism in the blood plasma of rats with alloxan induced diabetes. Blood plasma was extracted using chloroform-methanol mixture according to the Folch method. The total amount of lipids was determined by weighing the dry residue (gravimetric method). The division of lipids into classes was performed by thin-layer chromatography on silica gel. During the research, we found that the total amount of lipids, phospholipids, non-esterified cholesterol, triacylglycerols, non-esterified fatty acids, as well as the cholesterol-to phospholipid ratio increased in the blood plasma of rats with alloxan induced diabetes. However, the level of diacylglycerols and esterified cholesterol decreased. Given the consumption of vanadium citrate, the total levels of lipids, phospholipids, non-esterified cholesterol, triacylglycerols, and non-esterified fatty acids in the blood decreased, but the level of diacylglycerols and esterified cholesterol increased compared to the rats with experimentally induced diabetes. It was found that lipid metabolism is normalized in the blood of rats with experimentally induced diabetes that were watered with the solution of vanadium citrate in the amount of 0.125 μg/ml of water.

Oxidative stress is the outcome of an imbalance between the production and neutralization of reactive oxygen and nitrogen species (RONS) such that the antioxidant capacity of cell is overwhelmed. The present review briefly summarized the underlying role of overwhelming levels of RONS in the pathophysiology of diabetes mellitus (DM). The primary causative factor of oxidative stress in DM is hyperglycemia, which operates via several mechanisms. However, the individual contribution of other intermediary factors to hyperoxidative stress remains undefined, in terms of the dose response relationship between hyperglycemia and overall oxidative stress in DM. Intuitively, the inhibition and/or scavenging of intracellular free radical formation provide a therapeutic strategy to prevent oxidative stress and ensuing pathologic conditions.

Background: Presently snakebite has become a serious health problem in India.The actual incidence of mortality and morbidity related to the snakebite are not reported properly. Furthermore, the most neglected part is the long term endocrine dysfunction in survivors of russel viper envenomation. Materials and methods: Forty five survivors of russels viper bite patients were selected for the study according to inclusion and exclusion criteria. Admitted patients were treated accordingly and discharged in stable condition. The hormonal status were analysed and they have been followed up after 3 and 6 months. Results: Significant decrease in serum cortisol and prolactin were observed in survivors of russels viper bite patients particularly in those patients whose mean serum creatinine was more than 1.2 mg/dl and systolic blood pressure is more than 110 mm of Hg and diastolic Blood pressure is more than 70 mm of Hg. Conclusion: Measurement of long term hormonal status like serum cortisol and prolactin can be beneficial in survivors of russel viper bite patients.