Abstract: The purpose of the study was to find out the effect of specific training on cholesterol among university hockey players. To achieve this purpose of the study, thirty men hockey players were selected as subjects who were from the various faculties, Annamalai University, Annamalainagar. The selected subjects were aged between 19 to 24 years. They were divided into two equal groups of fifteen each, Group I underwent specific training and Group II acted as control that did not participate in any special training apart from their regular sports and games practices. The subjects were tested on selected criterion variable such as cholesterol prior to any immediately after the training period. The selected criterion variable such as cholesterol was to assess body fat monitor. The analysis of covariance (ANCOVA) was used to find out the significant differences if any, between the experimental group and control group on selected criterion variable. The 0.05 level of confidence was fixed to test the significance, which was considered as an appropriate. The result of the present study has revealed that there was a significant difference among the experimental and control group on cholesterol.

Abstract: Multiple myeloma is hematological malignancy characterized by a clonal proliferation of malignant plasma cells in the bone marrow secreting a monoclonal immunoglobulin. Approximately 20% of patients with newly diagnosed myeloma present with renal failure and it is the second most common cause of death in these patients. This study was undertaken to review the spectrum of cases of myeloma from an exclusive renal centre. Renal disease was present in all patients before myeloma was diagnosed. All the 36 patients showed 'M'spike in serum electrophoresis and deranged renal function. Renal diseases consisted of mainly of acute renal failure (51%), chronic renal failure (36%) and nephrotic syndrome (13%). Thus, acute renal failure is the most common renal disease preceding the diagnosis of myeloma. Hence it is necessary to look for potential renal impairment in myeloma patients as reversal of renal function can be achieved with chemotherapy and hemodialysis treatment.

Abstract: Lipoprotein (a) is independently associated with Atherosclerotic Cardiovascular Disease (ASCVD) and is referred to as the most atherogenic lipoprotein. It is synergistic with the effects of low density lipoprotein cholesterol (LDL-C). Unlike other major classes of lipoproteins that have a normal distribution in the population, plasma levels of Lipoprotein (a) / Lp (a) have a skewed distribution towards the lower end with 85% population having concentration <30 mg/dL. The aim of present study is to estimate the level of serum Lp(a) in cerebrovascular diseases or Strokes. The study was conducted in the Department of Medicine, Department of Biochemistry, Sushila Tiwari Memorial Hospital, the teaching hospital of Uttaranchal Forest Hospital Trust (UFHT) Medical College, Haldwani (Nainital), Uttarakhand, on patients of cerebrovascular disease (CVD) which included estimation of Lp(a) and lipid profile (TC, TG, HDLc, LDLc, VLDLc) test. Out of the 17 women and 36 men in whom Lp (a) was measured, 2 women (mean age63.5 years) and 21 men (59years) had CVD (CVD(+), while 15 women (50.13 years) and 15 men (52.33 years) had no CVD [CVD(–)]. As shown in Table 1, there were no significant differences between women with or without CVD in age and concentration of total plasma cholesterol. The study was based on a small sized cohort of 23 cases suffering from (CVD) out of which 21 were males and 2 were females. Thirty (30) healthy subjects were taken as controls, who were not suffering from any disease, which may affect serum lipid levels and without any history of cerebrovascular disease. Total-C, LDLc, VLDLc, Triglyceride, HDLc, LDL/HDL, Cholesterol/HDL and Lp(a) were estimated in all the cases.

Abstract: Syndrome Z is defined as the co-occurrence of obstructive sleep apnea (OSA) and metabolic syndrome. There is a paucity of information on the magnitude of syndrome Z in the community and the factors associated with it. Obstructive sleep apnea (OSA) has been linked to increased cardiovascular morbidity and mortality from both coronary heart disease and stroke [1-3] but whether this risk is due to coexistent known cardiovascular risk factors or specific effects of OSA remains to be established. In populations at risk of vascular disease, many patients who experience a cardiovascular event either do not have identifiable risk factors or have disease severity which appears to be out of proportion to their known risk factors. A lot of the variance in the incidence of vascular disease is therefore not explained by known risk factors. It is possible that OSA is a cardiovascular risk factor, previously largely unrecognized, which may account for some of the apparently unexplained variance in vascular risk. Systemic hypertension during daytime measurements of blood pressure is common in patients with OSA [8] but a causal link between these two conditions has been disputed [2, 3]. Sleep apnea has been shown to be common in patients with hypertension [8-11] and, conversely, patients with OSA have a high prevalence of hypertension [1, 5]. The frequency with which risk factors for hypertension such as increasing age and obesity coexist in patients with OSA has confounded identification of a causal relationship between OSA and hypertension.

Abstract: Main objective of this study is to utilize Agro wastes instead of pure sugars for cellulases productions. It was noted that maximum fungal cell growth was obtained 0.936g/100ml of Aspergillus niger was observed at pH 4.11 in hydrolyzed rice husk used as carbon source. Aspergillus niger was isolated from the soil of Khairpur. The collection and utilization of suitable Agro wastes used as a carbon source for cellulases production by fungi requirements optimized fermentation process. Five agricultural wastes were measured for cellulolytic enzyme production using pretreatment methods acid. Acid pretreatment was found to be the most efficient and best method for higher enzyme production. Using this cheap and renewable residue, for cellulolytic enzyme production by Aspergillus niger boosts its economic value which is not comparable with its current use as animal feed. Agro wastes such as sugarcane peelar bagasse, sugarcane bagasse, banana fruit stalk, sorghum husk and rice husk were hydrolyzed with 0.6N HCl. Rice husk was found good substrate in comparison to other Agro wastes for the growth of Aspergillus niger and cellulases production. Maximum activity of cellulases were noted 4.811 (units/ml). The Cellobiase and salicinase maximum production 4.717 and 4.742 units per ml obtained at 240 hours respectively.

Abstract: Glucose 6 phosphate dehydrogenase (G6PD) deficiency and Neonatal Hyperbilirubinemia. The Prospecutive study was conducted between June 2017 to June 2018 among icteric neonates in Maternity and Children Hospital, Nejran, Saudi Arabia. A total of 200 icteric neonates were included in study, who were admitted in nursery during study period. Each baby was tested for Complete blood count, Reticulocyte count, ABO and Rh blood types, Direct antiglobin test and quantitative G6PD estimation. Out of 200 icteric neonates 56( 28%) were found to be G6PD deficient and 144 (72%) had normal enzyme activity.38.7% were males and 12.3% were females among G6PD deficient neonates. Fisher exact test is 0.00 which is highly significant as p<0.001. None of them had kernicterus. Haemoglobin and Reticulocyte count in G6PD deficient neonates is statistically significant as p<0.01as compared to G6PD normal neonates. Since the Prevalence of G6PD deficiency in our neonates was relatively high. Early detection of this enzymopathy regardless of sex and close surveillance of affected newborn may be important in reducing the risk of severe hyperbilirubinemia.

Abstract:Thyroid hormones have many important biological functions in our body. One of the major functions is control of the basal metabolic rate and calorigenesis. Thyroid dysfunction causes remarkable changes in glomerular and tubular functions. In recent studies, it was found that hypo and hyperthyroidism associated with renal derangement resulting in abnormal serum creatinine and uric acid levels. Thus, this study was conducted for estimation and observation of changes in urea and creatinine in subclinical hypo and hyperthyroidism.Total 90 subjects were included in the study. Out of which 30 cases were clinically diagnosed subclinical hypothyroid patients and 30 were subclinical hyperthyroid, remaining 30 were controls. Triiodothyronine (T3),Thyroxine(T4), and TSH were estimated by fully automated Beckman coulter Access-2 analyser. Urea, uric acid and creatinine parameters were measured using automated clinical chemistry analyser. Statistical data analysis was performed by using SPSS 18.2 software. Patients with subclinical hypothyroidism showed significant increase in serum uric acid and creatinine levels (p<0.0001) and patients with subclinical hyperthyroidism showed significant decrease in serum creatinine levels (p<0.0001). When correlated with TSH, serum creatinine showed positive correlation where it has negative for serum uric acid in case of SC hypothyroidism cases. For SC hyperthyroid cases, correlation was negative for serum creatinine and uric acid levels.The overall result of our study indicate that the urea, creatinine, uric acid levels were significantly impaired in subclinical hypo and hyperthyroidism. Therefore, we would emphasize the importance of the routine evaluation of these biochemical parameters in thyroid disorders.