Flavonoids has been shown to have anti-inflammatory and anti-oxidant properties, which may have potential protective effects against mechanical induced models of pain. In this context, administering methanolic extract of artocarpus altilis (MEAA) during the experimental rats could potentially increase the pain threshold, which could in turn, increase the quality of health and life expectancy. Dearth literature exists on the analgesic effects of Bread fruit on pain. Hence, this study aims at investigating the potential anti-nociceptive properties of MEAA to increase paw withdrawal latency using murine model. 25 Wistar rats were randomly selected into five groups: Group 1=(control); Group 2, 3 & 4 (100, 200, 300-mg/kg MEAA, respectively) and Group 5=100-mg/kg Aspirin (ASP). The rats were subjected to mechanical pain-behavioral studies at 30, 60, 10 and 120 minutes after administration of test substances. Results obtained showed that, at 30 minutes post administration of MEAA and ASP, significant increase (p<0.05) in pain threshold was observed in 100, 200, 300-mg/kg and ASP groups when compared to control. At 60 minutes, significant increase (p<0.05) in pain threshold was observed in 200, 300-mg/kg and ASP groups when compared to control. Finally, at 90- and 120-minutes, significant increase (p<0.05) in pain threshold was observed in 300-mg/kg group only, when compared to control. In conclusion, graded doses of MEAA showed analgesic properties by increasing pain threshold when administered 30, 60, 90 and 120 minutes prior to subjection of the animals to mechanical pain. Therefore, MEAA have shown analgesic properties that could even be more effective than the reference drug (aspirin).