In the present research, the level of cancer antigen 125 (CA125) significantly increased in DMBA experimental groups (group II) compared to normal control group. However the level of CA125 decreased in dose dependent manner with 10% carbohydrate ketogenic diet having the most significant effect. Also, the 7,12-Dimethylbenz(α) anthracene (DMBA) caused significant increase in liver enzymes (Alanine amino transferase, Aspartate amino transferase and Bilirubin) of 41±1.06, 40±1.16, 20.80 ±1.47 and 25±1.34, 27±143, 12.17±1.08 compared to normal control at P<0.05 respectively. Furthermore, with the group treatment 10%, 20% and 30% carbohydrate ketogenic diets also elevated the liver enzymes. More so, a significant decrease was observed in total protein, albumin, RBC, Hb, PCV, MCH superoxide dismutase, glutathione reductase and glutathione peroxidase with a corresponding increase in white blood cells. Interestingly, ketogenic diets significantly increase total protein, albumin, superoxide dismutase, glutathione reductase, and glutathione peroxidase with a decrease in white blood cells, total cholesterol, triglyceride, low density lipoprotein bilirubin concentration. It can therefore be concluded that, the administration of ketogenic diets slows the progression of breast cancer through inhibiting the downstream of insulin receptors of both mammalian target of rapamycin signal cascade and motogen activator protein kinase pathways.

Background: Type 2 diabetes mellitus is a prevalent hereditary condition that has multiple genetic risk factors as well as environmental influences. Aim: The Work aimed to find if there is an association between the presence of Single Nucleotide Polymorphism of the Adiponectin gene & its association with type II diabetes in Egyptian patients. Material & Techniques: This case-control research had been conducted at Molecular Biology and Biochemistry, Genetic Engineering & biotechnology institute, university of Sadat city. This research had been conducted on eighty patients; separated into 2 groups diabetic group and the control group. Results: significant reduction in adiponectin level in type II diabetes studied cases compared to normal control subjects (p <0.001). GG genotype is significantly more predominant in type 2 diabetes (54%) while the GT genotype is more predominant in control (60%) (p-value =0.04)., while no variation in allele distribution among both groups (p value=0.6). Conclusion: In studied cases with type 2 diabetes, there was a significant reduction in adiponectin levels in type II diabetes patients. GG genotype is significantly more predominant in type 2 diabetes. The genotype GG significantly rises the risk of occurrence of type 2 diabetes.