REVIEW ARTICLE | Jan. 7, 2022
Perspectives in the Emergence and Re-Emergence of Infectious Diseases, Geopolitics and Gain-of-Function Research
Dr. Chrysanthus Chukwuma Sr
Page no 1-7
This paper attempts to present the dissemination and transmission dynamics of emerging and reemerging infectious diseases and the underlying features of gain-of-function research and geopolitics in the ambient within and across borders. Research and publication are relevant from perspectives in the management of local and global health because disease is perspicuously a geopolitical issue ostensibly linked to gain-of-function research where health diplomacy undergirds present and future global functionalities regarding the emergence and reemergence of infectious diseases. These have generated vehement reactions with propensity for extreme geopolitics and gain-of-function natural and anthropogenic activities. Geopolitical parameters and gain-of-function issues impact on the social determinants of health and vice versa. The convening and convergence of countries for unprecented epidemic or pandemic treaty settings or other formulations to confront emerging and reemerging infectious diseases will afford considerable opportunities concerning challenges in action, preparedness and response. Provisions are pertinent for legal instruments, effective and efficient systems to curb future threats and outbreaks of infectious diseases.
REVIEW ARTICLE | Jan. 21, 2022
Intrinsically Disordered Proteins, Structural and Functional Dynamics
Irum Naureen, Aisha Saleem, Hafiza Hira Rehman, Umar farooq, Iqra Iqbal, Tayyaba Sehar, Tahir Ali
Page no 8-14
The classical theory is that before being biologically active, proteins are assembled into a unique three-dimensional structure in terms of quality. These Intrinsically Disordered Proteins (IDPs) are very common in many genomes, including humans and play a key role in central cell processes such as transcription and translation, cell cycle, and cell signaling regulation. In addition, the proportion of proteins associated with various diseases such as cancer and neurodegenerative diseases is very high in IDPs. Therefore, considerable efforts have been made to elucidate the molecular mechanisms supporting the role of IDPs in Biology and disease through the use of experimental and computational methods. Animal models are needed for human genetic anatomy and better treatment options. Genetic disease Although some animals are used key models in academic and industrial research .There is a lot of stress in the anatomy of genetic diseases. The Genetic resemblance of rats and the humans from which is naturally occurring genetic disease, unique population. The availability of structure and complete genomic sequencing has made purebred dogs a powerful model. Used for disease research. The main advantage of dogs is that they suffer from about 450 genetic diseases, of which about half show significant medical symptoms, Similar to the same human disease. Therefore, these two facts make dogs an ideal medical practice, and a genetic model. This review sheds light on some of them, common genetic disease, in dog model. In this article plays an important role in identifying the genes responsible for the disease and / or the use of new genes, treatment of interest for dogs and humans.
REVIEW ARTICLE | Jan. 27, 2022
Therapeutic Role of Piper nigrum L (Black Pepper) and Pharmacological Activities
Aisha Saleem, Irum Naureen, Muhammad Naeem, Gulnaz Tasleem, Hassam Ahmed, Umar Farooq
Page no 15-21
Black pepper, the King of spices (Piper nigrum L.), is a widely used spice, known for its pungent odour. From time immemorial, plant sources were used in traditional systems of medicine and day-to-day common use, such as in meal preparation and cosmetic purposes. This is due to their vast pharmacological potential with beneficial effects. Among the various species of the Piperaceae family, black pepper is one of the most popular due to its principle pharmacological component, piperine. Which is an alkaloid that has diverse pharmacological activities like antioxidant, antiobesity, antitumor, antipyretic, anticonvulsant, antithyroid, antifungal, antibacterial, insecticidal, hepatoprotective, antiasthmatic, larvicidal, antihypertensive, antiinflammatory, antidiabetic, antidiarrheal, bioavailability enhancer, immunomodulatory, antiepileptic, antifertility, GI stimulant, lipid metabolism accelerator, anticancer, CNS stimulant, diuretic, aphrodisiac, blood purifier and antiplatelet activities, etc. Due to the some religious values of black pepper, its being popular from ancient times which is beneficial to modern generation. This review is aimed to provide a literature review on recent advancement of chemistry, pharmacognosy, pharmacological activities, new Piperine based formulations and other general use of Piper nigrum.
ORIGINAL RESEARCH ARTICLE | Jan. 30, 2022
High Sensitive C Reactive Protein (hsCRP) and Alkaline Phosphatase (ALP) in Type 2 Diabetes Patients
Nazrana Martuza, Rezwana Haque, Shamima Afrin, Abu Jafar Md Tareq Morshed, Afia Shahnaj, Md. Tufazzal Hossain, Mohammad Shiblee Zaman
Page no 22-27
Background: Diabetes is a group of metabolic disorders, characterized by hyperglycemia which results from defects in insulin secretion, insulin action, or both. The prevalence and incidence of type 2 diabetes are rising rapidly worldwide. Diabetes has been linked to a shorter life expectancy mainly because of its complications, including heart disease, strokes, retinopathy, and chronic kidney disease and bone disease. Objective: To examine the relationship between high sensitive C reactive protein (hsCRP) and alkaline phosphatase (ALP) in type 2 diabetic patients. Methods: This study was a hospital based cross sectional study conducted at Dept. of Biochemistry, Ashiyan Medical College Hospital from January to June 2020. The study consists of 180 patients out of which 90 were normal healthy controls (Group I) and 90 patients having type 2 DM were included in case (Group II). FBS, PPBS, HbA1c, hsCRP and ALP of all subjects were measured. Results: Mean serum hsCRP and ALP level were statistically significant higher in case group compared to control group. Moreover, significant positive correlation was observed between hsCRP and ALP level as well as both with FBS, PPBS and HbA1c. Conclusions: Oxidative stress and inflammation appears to be a key component and also associated with poor glycaemic control and further pathogenesis of diabetes and its complications. All our finding suggest a link between oxidative stress, inflammation and glycaemic control in patient with type 2 diabetes mellitus.