Background: One of the leading causes of cancer-related death in women worldwide, that causes an enhancednegative impact on quality of life with regard to social and economic burden, is Cervical cancer (CaCx). Early diagnosis and treatment can plummetassociated mortality and morbidity, by hit hard and early approach. Aim and objective: To estimate serum total antioxidant capacity (TAC), and malondialdehyde (MDA) in CaCx patients and analyse their response to chemoradiation. Materials and Methods: Histopathologically proven CaCx patients (n=50) and age-matched healthy females (n=50) were recruited in case-control study. Estimation of Serum TAC, and MDA was done in recruited subjects. Both of these parameters wasestimated again after chemoradiationin CaCx patients, to scrutinize the effect of chemoradiation. In addition, 84% controls and 34% cervical cancer patients had a history of Vit. C and E supplementation. Results: The mean +SD age of the patients and controls was 43.98±6.38 and 31.56±6.84 years, respectively. The mean level of serum MDA in the patients was significantly higher as compared with the controls, whereas the mean TAC in the patients was reduced in same comparison. After chemoradiation, serum levels of TAC and MDA, increased and decreased, respectively. Conclusion: These analytical data captured suggests that patients with CaCx were in oxidative stress because the chosen oxidative parameters, serum MDA were increased, and the defensive TAC was decreased in them. Chemoradiotherapy improved their antioxidant capacity. Further studies are needed to evaluate the concurrent use of antioxidants with chemoradiotherapy for improving the disease prognosis.