Pleurotus tuber reguim is a mushroom widely used as food, and in traditional medicine for weight loss and treatment of headache, fever and stomach pain among other ailments. This present study is aimed at the evaluation of antihyperlipidemic activities of chromatography fractions obtained from an earlier reported anti-hyperlipidemic chloroform extract of Pleurotus tuber reguim using triton X-100 induced hyperlipidemic rat model as well as investigate the phytochemical constituent(s) from the active chromatography fraction(s). The pulverized sclerotia sample was extracted exhaustively by cold maceration with chloroform and the chloroform extract (6.42g) fractionated on a chromatography column(silica gel G, 200 -400 mesh-stationary phase) eluting with a gradient mixtures of n-hexane: chloroform: methanol (4:0:0; 3:1:0; 1:3:0; 0:1:0; 0:3:1; 0:2:2; 0:1:3; 0:4- v/v/v). Fractions with similar chromatography fingerprint on thin layer chromatography examination were pooled. Phytochemical screening was done using standard methods. The chloroform extract afforded four pooled chromatography fractions (F1, F2, F3 and F4). The trend: Total cholesterol [atovastatin (47.5%) > F1 (42.3%) > F2 (37.6%) > F4 (29.9%) > F3 (29.8%)]; Triglyceride [F4 (47.6%) > F1 (44.8%) > Atorvastatin (35.6%) > F3 (32.9%) > F2 (4.3%)]; High density lipoprotein-cholesterol [F2 (101.3%) > F1 (91.2%) > atovastatin (53.7%) > F3 (17.7%) > F4 (14.9%)];Very low density lipoprotein-cholesterol [F4 (47.6%) > F1 (44.8%) > Atorvastatin (35.7%) > F3 (32.9%) > F2 (4.3%)]; Low density lipoprotein-cholesterol [Atorvastatin (12.5%) > F2 (10.0%) > F1 (7.6%) > F3 (3.5%) > F4 (-4.9%)]. Fractions F1 and F2 where found to contain triterpenoids and fatty acids while fractions F3 and F4 were found to contained amino acids or peptide derivatives. Pleurotus tuber reguim exhibited hyperlipidemic activity and the presence of triterpenoids and amino acids or peptide derviatives could be responsible for the observed trend in antihyperlipidemic activity.

The associations between Bisphenol A (BPA) exposure with prolactin and progesterone hormone levels is been considered globally. A three months study was conducted with female albino rats exposed to BPA. The blood samples were collected for assay of prolactin (PRL), and progesterone (PROG). A significant positive association between increased BPA concentration and higher PRL and PROG levels were observed. The results suggest that BPA exposure may lead to alterations in female reproductive hormone levels.

SARS-CoV-2, the etiologic agent of the COVID-19 pandemic, spatiotemporally evolves or mutates to its variant with potentialities for adverse opportunistic infections via replications and transmissions or disseminations. The dissemination and transmission of the Delta variant is accelerating more than expected partly due to unvaccinated persons not treating the pandemic as seriously as necessary. The test and tracing service must be effected because a vast proportion ofthe population is unprotected. It is crucial to restrict movements. Vaccinated persons must socialize indoors in well-ventilated ambients, and avoid non-essential foreign travels. The evolution of the COVID-19/SARS-CoV-2 pandemic portends a well-nigh impossible termination of events. It is, therefore, imperative to focus on the cost and not merely the opportunity cost to control the never-ending SARS-CoV-2/COVID-19 pandemic. There is the need to make public health system a priority with emphasis on cost sharing and cost saving for vaccines and other healthcare modalities to reach the poor and the vulnerable populations in developing countries and elsewhere for safety and protection of lives through enhanced substantial, restorative and sustainable financing,technical expertise and capacity building.