Background: The hyoid bone is of considerable forensic interest because of its susceptibility to fracture during manual strangulation, hanging and other forms of neck compression. It is also frequently injured in road traffic accidents and may cause significant airway concerns. Whatever may be the reasons, why only some hyoid bones fracture and others do not may be related to the nature, magnitude, position of force applied to the neck, age of victim, nature of instrument (ligature or hand) used to strangle and anatomical features of the hyoid bone such as rigidity, shape of the bone and symmetry of greater horns. Aim: To know the incidence of symmetry and isometry of human hyoid bones in both sexes. Materials & Methods: Present study includes 60 hyoid bones (male: female, 30:30) collected from the cadavers of known age and sex during autopsies (October 2013 to April 2016) at Mysore Medical College and Research Institute, Mysore. Numbering the bones was done with prefix M/F (M-male, F- female).Their outline was drawn on the graphpaper to study the symmetry and isometry of the bone. Results: 50% of the hyoid bones were symmetrical (M:F – 45%:54%) while remaining 50% were asymmetrical (M:F – 54%:45%). Anisometric bones were more (58%) as compared with isometric (42%) bones in both the sexes. In males 17 bones were anisometric, 13 bones were isometric where as in females 18 bones were anisometric, and 12 bones were isometric. Conclusion: Hyoid bone is not bilaterally symmetrical bone.