ORIGINAL RESEARCH ARTICLE | April 3, 2024
Oxidative Stress Markers Evaluation after Prolonged Administration of Aqueous Extract of Raphia Hookeri Fruit Pulp in Male Wistar Rats
Egbono, F. F, Udeh, W. C, Ogbonna, U. N
Page no 6-16 |
DOI: 10.36348/sijap.2024.v07i02.001
The study investigated effect of prolonged administration of Raphia Hookeri fruit pulp on oxidative stress markers in male wistar rats. A total of 24 male wistar rats of weight ranging from 200g to 350g were used. The rats divided in 4 groups, 3 groups administered orally with doses of extract at 500mg/kg, 1000mg/kg and 2000mg/kg body weight while control group fed with feed and water for 28 days. The animals sacrificed, samples taken, laboratory test done for stress markers. Statistical analysis done at p<0.05, values expressed as SEM. Results showed Malondialdehyde (MDA) values for group 2(0.77 ± 0.32nm/ml), group 3(1.79 ± 0.73nm/ml) and group 4(3.35 ± 0.20nm/ml) while for group 1(Control group) MDA value is 4.10 ± 0.3nm/ml. Mean values for Superoxide Dismutase (SOD) in treated groups (2-4) were 18.00 ± 1.0 units/ml, 29.50 ± 8.50units/ml, and 33.50 ± 37.25units/ml respectively and mean value for control group was 68.00 ± 4.0units/ml. Mean values for Glutathione Peroxidase (GPx) in test groups (2-4) were 53.50 ± 10.50ng/ml, 63.50 ± 5.50ng/ml, and 82.50 ± 6.50ng/ml respectively. GPx value for control group was 94.00 ± 3.00ng/ml. There was a graded increase from low dose to high dose. All treated groups indicated marginally (P>0.05) reduced values of Percentage change in body weight when compared to the control group (Group 1). Elevated levels of MDA indicates an increased oxidative stress and lipid. Higher levels of SOD and Gpx. This research demonstrates the ability of Raphia Hookeri fruit pulp to decrease oxidative stress hence regular consumption is recommended.
ORIGINAL RESEARCH ARTICLE | April 5, 2024
Virtual Dissection Table: A Supplemental Learning Aid for Head and Neck Anatomy in a Physical Therapy Program
Martín G. Rosario
Page no 17-24 |
DOI: 10.36348/sijap.2024.v07i02.002
Although cadaver dissection and prosection are considered essential techniques for studying anatomy, their effectiveness is hindered by the use of flat, 2-D structures in didactic portions of anatomy courses. The limitations of this particular method can greatly hinder students' comprehension and grasp of anatomy, ultimately limiting the overall effectiveness and quality of the teaching and learning experience (TLE). In order to enhance the TLE and improve students' understanding of gross human anatomy, there are a variety of tools that can be utilized, including 3-D virtual anatomy applications and anatomical models. These resources provide a visual and interactive approach to learning, allowing for a more comprehensive understanding of the complex structures of the human body. The Anatomage, a virtual anatomy dissection table (VDT), is a highly sophisticated advancement that enables the dissection and prosection of the human body and its segments. The primary objective of this research project is to delve into integrating a VDT into a physical therapy anatomy course for a complex topic like head and neck, with the aim of enhancing the TLE and comprehension of anatomical concepts of said area. The methods encompass the inclusion of the VDT as an extra dissection table within the cadaver lab setting. Each group of scholars was given the responsibility to locate and study the assigned anatomical configurations and dissections on the VDT, specifically for their designated topic. Based on the results of our study, it can be inferred that there have been improvements in knowledge retention among students after the introduction of the VDT in the cadaver dissection segment of the course for head and neck. As a result of our research and analysis, we have come to the conclusion that the VDT is an exceptional tool that should be implemented in anatomy courses to help students understand intricate anatomical structures. The integration of the VDT is an essential and crucial step in the process of assimilating and applying human anatomy knowledge for students pursuing careers in the healthcare field.
REVIEW ARTICLE | April 8, 2024
Clinical Implications of Anatomical Variations in the Sinonasal Region on Sinus Pathology: A Systematic Review
Abdul Malik, Shakera, Mohd Abu Bakr Quadri, Sohrab Husain
Page no 25-28 |
DOI: 10.36348/sijap.2024.v07i02.003
Hippocrates, the "Father of Rhinology," provided detailed descriptions of nasal polypoidal tumors and nasal complex from 460-370 B.C. His writings are the earliest known sinus anatomy, with anatomists studying primates and mammals focusing on paranasal air sinuses. This systematic review explores the link between anatomical variations in the sinonasal region and sinus pathology, providing a comprehensive understanding of the prevalence, types, and clinical implications, thereby aiding clinicians in making informed decisions and improving patient outcomes. A thorough search of PubMed, Google Scholar, Research Gate and PRISMA guidelines were used to perform this review, with subjects related to the study's title as the primary search criteria. We used the following search terms: nasal blockage, paranasal sinus, sinus pathology, and nasal-respiratory complex. Anatomical variations in the ostiomeatal complex, found in 83.5% of cases, significantly impact sinus drainage and ventilation, leading to sinus pathology. Variations like deviated nasal septum, concha bullosa, and agger nasi cells obstruct mucus and air flow, causing sinusitis. Studies show a clear association between anatomical variations and chronic sinusitis, highlighting the importance of considering these variations when evaluating patients with sinus pathology. Nasal polyps are another common pathology associated with anatomical variations in the sinonasal region. Sinusitis is the most common condition affecting the nose and paranasal sinuses, which are affected by trauma, tumors, and sphenoid sinuses. Staphylococcus bacteria, found on skin and nasal cavities, can infect people. Sinonasal disease encompasses a range of illnesses, from inflammatory to malignant, and is the fifth leading cause of antibiotic use and the highest frequency across all age groups. Research indicates a correlation between anatomical variations in the sinonasal area and sinus pathology, particularly in patients with chronic rhinosinusitis. Careful assessment and CT are crucial for identifying and treating these variations. Further research is needed to fully understand the clinical implications of these variations, as they can significantly impact sinus pathology and the management of sinus conditions.
ORIGINAL RESEARCH ARTICLE | April 30, 2024
Enhancing Gross Anatomy Courses in Occupational Therapy with 3D Applications: An Assessment of Effectiveness
Martín G. Rosario
Page no 29-34 |
DOI: 10.36348/sijap.2024.v07i02.004
Traditional teaching methods, such as two-dimensional PowerPoint presentations, are prevalent in anatomy education but must provide an in-depth perception of anatomical structures. This article discusses integrating 3D anatomy application in an Occupational Therapy course as an advanced technique for anatomical learning. The "Complete 3D Anatomy" app was employed to facilitate the teaching of anatomy structures. Students from 2 different cohorts, 93 from 2022 and 96 from 2023 test scores, were considered in this endeavor. The 2022 group used the 3-D app on their own time, compared to the 2023 group, who were required to use it in class for every lecture by the instructor. Results showed improvement in their test score from 71% (2022) to 87% (2023), with the integration of the 3-D as a class activity. Based on these results, it is concluded that the 3D anatomy app is an essential tool for comprehensive anatomical learning. For future courses, there is a plan to integrate further and assess the benefits of requiring students to employ a tablet or iPad equipped with 3D apps, along with a virtual dissection table to complement teaching and learning enterprises in the human cadaver laboratory.