Introduction: The osteometric dimensions of the lower end of the femur have significant clinical implications, particularly in the context of total knee arthroplasty (TKA). Accurate measurements are crucial for the design of femoral components in TKA, which can influence surgical outcomes. This study aims to determine the measurements of different variables of the lower end of the femur, including femoral condylar width, intercondylar width and depth, and the depth of the medial and lateral condyles, in a Bangladeshi population. Methods: This cross-sectional study was conducted on 50 dried femurs collected from three medical colleges in Dhaka, Bangladesh. Measurements were obtained using digital sliding calipers and were rounded to two decimal places. Data analysis was performed using SPSS. Result: Statistical analysis revealed that 56% of the femurs were right-sided and 44% were left-sided. The mean femoral bicondylar width was 69.78 ± 5.38 mm, falling mostly in the "Above Average" range (30%). The mean intercondylar width was 23.77 ± 1.55 mm, with 50% falling in the "Medium" range. Other variables like femur medial condylar width had a mean of 31.05 ± 1.74 mm. Conclusion: Observationally, the study successfully delineates the osteometric dimensions of the lower end of the femur in a Bangladeshi cohort. The statistical results not only fulfill the study's initial aim but also provide a nuanced understanding of the osteometric variations. These findings are instrumental for clinicians in the design and customization of femoral components in TKA, thereby potentially enhancing surgical outcomes and patient satisfaction. The data also lay the groundwork for future research in this area.

Chronic recurrent seizures is a characteristic feature of epilepsy. It is a chronic neurological condition, usually resulting in unpredictable, unprovoked recurrent seizures that affect a variety of mental and physical functions. Some motor functions appear vulnerable to these seizure disorders. This study investigated the neurobehavioural analysis of pentylenetetrazole (PTZ) induced seizure on motor balance, coordination in Wistar rats. The study was done in two phases: acute (14days) and chronic (28days). A total of twenty adult Wistar rats weighing between 90-120g were used for each phase of study. The rats were divided into four (4) groups (1-4, n=5). PTZ was administered intraperitoneally to the PTZ treated groups one (1) week before the neurobehavioral experiments commenced. Group 1 (control) received distilled water; groups 2, 3 and 4 were administered with subconvulsive doses of PTZ (25mg/kg, 30mg/kg and 35mg/kg) respectively at alternate days (48 hourly) until kindling was achieved. The study evaluated neurobehavioural parameters using Rotarod test (RT) and Handgrip test (HT). In both tests, the time latencies were significantly (P<0.05) reduced and worsened with time, when test groups were compared to control either in acute or chronic phase study. The results from the current study on the effects of the chemoculvosant seizures on motor functions, coordination and balance shows that severity and chronicity of seizures caused a deficit in motor coordination and balance. In conclusion, seizure disorder disrupts motor activities.

Obesity and pulmonary diseases are said to be co-prevalent and debilitating chronic illnesses that are becoming more and more commonplace globally. This study thus, evaluated the changes in basic pulmonary indices of obese women resident in Rivers State, Nigeria. The minimum sample size of 272 was determined using the Leslie Fischer's formula; exactly 334 obese and non-obese women within their 18 and 65 years of age with no critical health condition and resident in Upland and Riverine areas of Rivers State were actually surveyed by the present study. A multistage sampling technique was adopted, and subjects were surveyed across the upland and riverine locations of the State. These subjects were evenly drawn from the multi-ethnic residents of the state. Automated spirometer was used to measure forced vital capacity (FVC); forced expiratory volume in 1 second (FEV1 and forced expiratory volume in 1 second (FEV1) and forced expiratory volume in 6 second (FEV6) and the FEV1/FVC ratio. The quantitative data were subjected to statistical analyses using the statistical package for social sciences (SPSS) version 21.0. One-way analysis of variance (ANOVA) and independent t-test with a p< 0.05 considered statistically significant were determined. The result indicated that the obese subjects had reductions in some pulmonary indices, like FVC levels. On the other hand, the FVC/ FEV1 ratio had significant (p<0.05) increases following increasing BMI. Further evaluations on the actual impact of obesity on FVC/ FEV1 ratio may shade more light in this direction.

Background: Background: Phytochemicals are plant bioactive compounds that are produced for their protection with some having medicinal value. Craterostigma plantagineum hoscht is a plant that is purported to have medicinal value and is used for treatment of pain, liver and diarrheal ailments. Extensive researches on phytochemicals present in Craterostigma plantagineum hoscht are missing. The aim of this study was to determine qualitative phytochemicals yield in ethanol and aqueous extracts of Craterostigma plantagineum hoscht. Materials and methods: Craterostigma plantagineum hoscht was harvested and allowed to air dry for one month. Grinding into powder form later followed this. Solvents used included 70% ethanol and distilled water. 500mg of Craterostigma plantagineum ground powder was soaked in 70% ethanol for 48 hours, filtered and vaporized in rotary evaporator. Aqueous extraction involved soaking of 500mg of ground powder in 250 millilitre distilled water, set in a shaker for 2 days, filtered, deep frozen for 48 hours and finally freeze dried for 72 hour. Chemicals used to test phytochemicals included 1% gelatin, chloroform, ferric chloride, sulphuric acid, lead acetate solution, magnesium turnings, 10% sodium chloride, acetic anhydride, Mayer’s reagent, ammonia and hydrochloric acid. Results: The yield included flavonoids, Saponins, tannins, cardiac glycosides, phenols, anthraquinones, alkaloids, terpenoids and sterols. Tannins, anthraquinones, flavonoids, sterols, cardiac glycosides, Saponins, and phenols were highly extracted in ethanol while aqueous extract yielded more alkaloids and terpenoids. Conclusion and recommendations: Ethanol extraction yielded more phytochemicals than aqueous. Nonetheless, some phytochemicals were better extracted in ethanol while others in aqueous making the choice of extraction method dependent on the phytochemical of interest.

Doxorubicin-induced cardiotoxicity is the leading cause of morbidity and mortality among cancer survivors. The present study aimed to investigate the ameliorative effect of 5, 7-dihydroxyflavone (chrysin) against doxorubicin-induced cardiotoxicity in Wistar rats. Thirty-five adult male Wistar albino rats were randomly allocated into seven groups (n = 5 each) which consisted of normal control (group 1) receiving phosphate buffer saline (0.4 ml), positive control (Group 2) received 2mg\kg of doxorubicin (DOX) through an intraperitoneal route once weekly for 21 days, chrysin low dose and chrysin high dose (Group 3 and 4) received oral administration of chrysin 50&100mg/kg for 21 days, chrysin low dose and DOX, chrysin medium dose and DOX and chrysin high dose and DOX(group 5, 6, and 7) received 2mg/kg of DOX once weekly with 50, 100 and 150mg/kg of chrysin for 21 days. Significant elevations in cardiac troponin I (cTnI) and histological lesions, which corresponded with oxidative stress, inflammation, apoptotic indicators, and cardiotoxicity when compared to controls, were indicative of DOX-induced cardiotoxicity. Malondialdehyde (MDA), a sign of oxidative stress, SOD, CPK (creatinine phosphokinase), TBARS (thiobarbituric acid reactive substance), and CAT (catalase) were also elevated in the DOX group. The DOX group also had increased levels of cardiac inflammatory markers, including as interleukin-1 (IL-1), interleukin-6 (IL-6), and the apoptotic marker caspase-3. 5, 7-dihydroxyflavone (chrysin) significantly mitigated, but did not entirely reverse, the cardiotoxicity caused by DOX by reducing the histopathological scores of cardiomyopathies and lowering cTnI in comparison to the DOX group. Additionally, chrysin reduced MDA to substantially similar levels as the control. Following chrysin administration, significant decreases in IL-1, IL-6, and caspase-3 were also seen in comparison to the DOX-only group. All things considered, these findings point to chrysin's protective action against DOX-induced cardiotoxicity, which may have been rendered possible by oxidative stress, inflammatory, and apoptotic suppression.

Phytomedicine has become popular among and majority of women depends on herbal medicine when seeking healthcare. Several women opted for herbal medicine when looking for fertility and most the women that hormonal imbalance depends on herbal medicine for correction. Hormones is substance that must be required and must be in the right values for reproduction to occur. The aim is this study is to ascertain the Effect of aqueous leave extract of D. alba ness (Thorn Apple) on gonadotropic hormones (FSH, LH) Treated with monosodium glutamate (MSG) and clomiphene citrate in female wistar rats. The animals were randomly selected into 7 with five animals per group. Each group received the following: group 1 10mls/kg of distil water, group 2 low dose of extract (1000mg/kg), group 3 high dose of extract(2000mg/kg), group 4 MSG 800mg/kg, group 5 clomid 50mg/kg, group 6 MSG + high dose of extract and group 7 clomid+ high dose of extract. Administration of extract was done for 21 days, and on the 22nd day, the animals were sacrificed and blood samples were collected for hormonal analysis. The results revealed significant decreased in the serum levels of follicle stimulating hormones (FSH) in all the treatment groups (extract 1000mg/kg, extract 2000mg/kg, MSG 800mg/kg, MSG 800mg/kg + extract 2000mg/kg, and clomid 50mg/kg + extract 2000mg/kg) when compared with control and significant increase in serum levels FSH in clomid 50mg/kg treated group. Luteinizing hormone (LH) serum levels significantly decreased in all the treatment groups when compared with the control group. LH levels in the clomid group significantly increased when compared with other treatment groups. The statistical analysis was carried out using Statistical Package for Social Science (SPSS) version 23.