Neonatal sepsis (NNS) is invasive infection, mostly bacterial, occurring during the neonatal period. NNS manifests with ill-defined symptoms, therefore, requires high index of suspicion for early diagnosis. Neonatal sepsis is becoming less frequent due to improved obstetrical management and evidence-based use of intrapartum antimicrobial therapy. However, early-onset sepsis remains one of the most common causes of neonatal morbidity and mortality in the preterm population.

Verrucous carcinoma (VC) a low-grade variant of squamous cell carcinoma (SCC) is the rarest of all oral cancers. A hybrid VC is a non-verrucous SCC that arises synchronously with the VC.The differential diagnosis of VC remains difficult and requires clinical and pathologic data confrontation.As the malignant behaviour of hybrid VC is confined to the non-VC component, careful examination of these tumors is needed .here we report a case of 44 year old female with hybrid verrucous carcinoma.Clinical and histological features and treatment are discussed with the review of literature.

The adolescent period, is a unique developmental stage which is characterized by physical, psychosocial, social and cognitive changes as transition from childhood to adulthood. In this communication, we highlight the importance of establishing adolescent medical service, and call on the higher strategic planners in Saudi Arabia to establish a country wide program to improve the health wellbeing of the youth.

In this paper, we propose a non-monotone trust region method for solving unconstrained optimization problem. Unlike the traditional trust region methods, our new algorithm is simple by combining non-monotone strategy with a scale approximation of the objective function’s Hessian. Theoretical analysis indicates that the new method preserves the global convergence under some mild conditions.

We consider non-monotone wedge trust region method for derivative-free optimization. Throughout our knowledge, this is the first investigation paper which combining non-monotone strategy into wedge trust region methods. The computational results proved the efficiency of the new composite strategy.