The pervasive spread of Parthenium hysterophorus, a noxious weed native to the subtropical regions of the Americas, poses significant threats to biodiversity, human health, and environmental stability. Known by various names such as white head weed, congress grass, and Santa Maria feverfew, Parthenium has invaded numerous countries. This review highlights the adverse effects of Parthenium on agricultural productivity, native plant communities, and human and livestock health. The weed's allelopathic properties inhibit the germination and growth of surrounding flora, leading to substantial biodiversity loss and ecosystem disruption. Parthenium's prolific seed production, rapid spread, and adaptability to diverse environmental conditions facilitate its dominance, often resulting in the near-complete displacement of indigenous plant species. The health impacts on humans include allergic reactions such as dermatitis, bronchitis, and hay fever, while livestock consuming the weed suffer from alopecia, dermatitis, and reduced milk and meat quality. Effective management strategies are crucial for mitigating the spread and impact of Parthenium. These include physical removal, chemical herbicides, biological control agents, and the use of allelopathic plants. Despite ongoing efforts, challenges such as herbicide resistance and socio-economic constraints persist, necessitating continued research and integrated weed management approaches. Future directions should focus on understanding herbicide resistance mechanisms, exploring sustainable management practices, and leveraging emerging technologies like remote sensing and genetic engineering for precision management. Community involvement and public awareness campaigns are also essential for successful long-term control. This comprehensive review underscores the urgent need for coordinated efforts to manage Parthenium invasions and protect biodiversity, human health, and environmental integrity.