Crimean-Congo hemorrhagic fever (CCHF) is a condition brought on by a virus (Nairovirus) that is spread by ticks and is a member of the Bunyaviridae family and the genus Hayalomma. This virus could travel across the Hayaloma genus. This species maintains two host-life cycles, changing from a larva to a nymph on its first host, which can be a tiny animal like a bird, and then from adult stages to humans, which serve as the second host. Currently, 27 distinct Hyalomma species are recognized. Geographically, CCHFV is spread throughout Asia, the Middle East, Southern Europe, and Africa, all of which have large tick populations. This virus is capable of spreading both horizontally and vertically. Animals like sheep, goats, cattle, and hares may act as hosts or reservoirs for the virus. Humans can contract this virus by coming into touch with infected ticks or animal blood. Due to contact with bodily fluids or infectious blood, medical personnel are most vulnerable in endemic areas. This virus can cause symptoms such as high fever, joint discomfort, headache, back pain, vomiting, and stomach pain in infected individuals. To identify this virus, scientists employ the ELISA and RT-PCR methods. The medicine ribavirin and some readily available vaccinations can also be used to treat this virus. The effectiveness of using the vaccines and medications that are now available to treat this virus cannot be proven. The effectiveness of the vaccine to protect against this virus was investigated using a small animal model, such as a knockout mouse.