Background: Various liver disorders require histological assessment for proper diagnosis, staging, treatment, or follow-up. We determine indications and histological outcomes of liver biopsy samples. Materials and Methods: Sixty-two patients were consecutively recruited from four health centers within Sokoto metropolis over a five-year period (March 2019 to February 2023). Fifty one subjects that consented had a liver biopsy done for various indications. The tissues obtained were taken for histopathologic evaluations. Results: In the majority of the subjects, 39 (76.5%) the clinical indications for liver biopsy was Chronic viral Hepatitis infections (CVHI) while 7(13.7%) and 5(9.8) of the subjects had clinical indications of unexplained liver mass and fatty liver disease respectively. In all, fifty one subjects had liver biopsy. Histological outcomes were: Chronic Hepatitis 37 (72.5%), followed by HCC with 6 (11.8%), steatohepatitis 4(7.8%) then one subjects each for steatosis and secondary metastasis to the liver. Among the subjects with histological findings of Chronic Hepatitis majority of them either having mild necroinflammation 13(35.1%) or moderate necroinflammation 14(40.5%). Significant fibrosis was found in over 40% of the patients, with 2(5.6%) having histological conclusion of liver cirrhosis. The degree of inflammation and fibrosis from chronic hepatitis was not statistically significant between genders. Conclusions: Despite advancements made in available facilities in diagnosing liver diseases, tissue still plays a significant role. This is particularly so in regions with hyper- endemicity for CHBVI and low socio-economic standards.

Ocular involvement related to treatment with tumor necrosis factor alpha inhibitors is a rare adverse effect that may lead to irreversible outcomes. We illustrate through this report a case of optic atrophy under Etanercept in a patient with spondyloarthritis. The diagnosis was suspected due to visual acuity impairment, and was confirmed by ophthalmological examination. Although the TNF-blockers were discontinued and corticosteroids were administered, the follow-up examination did not reveal any improvement in visual acuity. This is a potential serious complication of TNF inhibitors that rheumatologists should recognize when monitoring patients with rheumatic diseases.

This study investigated the impact of CEO Shareholding on discretionary accrual of listed firms on the floor of the Nigerian Stock Exchange. The study used the ex-post facto research design. This informed the reliance on secondary data obtained from the published annual reports and accounts of a sample of eighty-six (86) non-finance companies and the sample size was determined via the Taro Yamane Formula. The study employed judgmental sampling technique based on certain criteria. The study employed CEO Shareholding (independent variables) while discretionary accruals via the Modified Jones Model. (Dependent variable) Both descriptive and inferential statistics were employed in the analysis of data. The major findings derived from this study CEO Shareholding insignificantly affect discretionary accrual. The study recommends that share-based option of executive compensation given to top business executives be encouraged as this has the tendency of increasing organizational productivity, efficiency and help reduce dysfunctional behavior among chief executive officers since their investments are also as stake, hence there will be goal congruence and the resultant effect reducing dysfunctional behavior. In addition, this study contributes to knowledge by providing empirical evidence that CEO Shareholding are not prime instigator of discretionary accrual in non –financial sector of Nigeria listed companies and the developed model can be used by researchers in both developed and developing countries.

Money laundering is a stand-alone crime, although money laundering is born from its original crime, such as corruption, but the anti-money laundering regime in almost all countries places money laundering as a crime independent of its original crime. In handling narcotics criminal cases, the suspect's wife is sometimes made a suspect in a money laundering crime. Seeing this, clear restrictions are needed in order to achieve legal certainty, legal protection and justice for wives who are determined to be perpetrators of money laundering crimes. This is qualitative research using a statutory approach, case and conceptual approaches. The primary legal materials resulted from relevant laws and legislation. The legal material collected is analysed prescriptively. The results show that there is a difference in treatment of the perpetrator's wife in almost the same narcotics criminal cases, indicating that investigators in money laundering criminal cases do not yet have standard procedures. Hence, the assessment is based on the investigator's subjectivity. As a special crime, the crime of money laundering requires formulating procedural law that is different from ordinary criminal procedural law.

Background and Objectives: Budd–Chiari syndrome is a vascular disorder of the liver which can cause fulminant liver injury and lethal portal hypertension-related complications. It is a rare disease and can be primary or secondary. The objective of our work is to detail evolution, treatment of patients with BCS and MPN according to the experience of a Moroccan center. Patients and Methods: This is a retrospective and descriptive study in the university hepato-gastroenterology department including all patients with BCS and MPN with portal hypertension (PH) over a period of 29 years. All our patients benefited from an etiological work-up and morphological explorations. Results: Out of a total 29 patients had BCS, 4 had MPN with a prevalence of 10%. Clinically, the signs of decompensated PH were predominant. Imaging confirmed BCS. The etiological work-up showed that all our patients had essential thrombocytemia. We had also association of other prothrombotic factors in 50 % of cases and a portal thrombosis in 25% of cases. Our patients had received treatment for the causative disease and treatment of thrombosis associated with the treatment of PH complications. The evolution was marked by the death of 2 patients (50%). Conclusion: The strong association between MPN and BCS is well established. The knowledge of the molecular mutations underlying MPN has dramatically improved in the last decade, allowing early diagnosis of MPN in a significant portion of BCS patient.

This study investigates the optimization and prediction of non-elastic performance factors required to augment the pipeline weldments' structural integrity and strength. The study's main focus is on the components of the operation, like the welding current, voltage, and gas flow rate to optimize and predict the corrosion rate of the pipeline weldment. Utilizing Design Expert software for experimental design and data analysis, the study employs the Central Composite Design (CCD) methodology to generate a quadratic model that predicts the responses effectively. The research also integrates Artificial Neural Networks (ANN) to further enhance the prediction accuracy. Experimental results indicate that the optimal welding parameters 160 amps current, 21.28 volts voltage, and 14.67 liters/min gas flow rate—yield a corrosion rate of 0.018 mm/yr. The study concludes that both RSM and ANN can be effectively used for optimization and prediction in welding processes, with RSM showing slightly better predictive capabilities.

Background: Sexual abuse in adolescents is a global public health issue with severe physical, psychological, and long-term effects. In Bangladesh, societal stigma, underreporting, and weak legal enforcement further exacerbate the issue. Objectives: The primary objective is to evaluate the prevalence and patterns of sexual abuse among adolescents in three Dhaka schools, with secondary objectives to assess their clinical, demographic, and mental health status. Method and Materials: This cross-sectional study aims to evaluate the prevalence of sexual abuse among 130 adolescents (aged 13-19) from three private schools in Dhaka, selected through purposive sampling. Data will be collected using a pre-tested questionnaire administered by trained research assistants. The data will be analyzed using SPSS and STATA for both descriptive and inferential statistics. Result: The study included 130 adolescents, with boys making up 53.8% and girls 46.2%. The most prevalent form of sexual abuse was verbal abuse, reported by 46.2% of participants, followed by physical touch (30.8%) and online abuse (15.4%). Peers or schoolmates were the primary perpetrators in 38.5% of cases, while 19.2% reported abuse by strangers. Notably, 46.2% of the adolescents did not report the abuse to anyone. Of those who did, 30.8% informed school authorities, and 23.1% confided in their family. Conclusion: Children, particularly girls, are highly vulnerable to sexual abuse due to lack of parental awareness, weak reporting systems, and difficulty in disclosing abuse. Strengthening community vigilance and reporting mechanisms is essential to protect them.

We report a case of Clostridium limosum lung abscess in a 71-year-old male heart transplant recipient. The patient presented with a week-long history of productive cough and confusion. His medical history included nonischemic dilated cardiomyopathy, chronic renal disease, and past Klebsiella pneumoniae bacteremia, among others. Imaging revealed a thick-walled cavitary lesion in the right lung, initially suspected to be a pulmonary abscess. Lung biopsy culture confirmed the presence of Clostridium limosum, a rare pathogen in humans, typically associated with farm animals. Following six weeks of Piperacillin/Tazobactam treatment, the patient showed significant clinical improvement. This case emphasizes the importance of considering zoonotic pathogens in immunosuppressed patients, especially those with occupational exposure.

Background: Dengue fever is a mosquito-borne viral disease that has emerged as a significant public health concern in Kolkata, with a substantial burden on the healthcare system. Also, this disease shows and additional impact on liver. Objective: To investigate the epidemiological trends of dengue fever in Kolkata and its effect on liver function. Methods: A retrospective study was conducted using data from [Ashok Laboratory] in Kolkata. Patients diagnosed with dengue fever between [July, 2023 to June, 2024] were included. Demographic, clinical, and laboratory data were analyzed. Results: A total of [6132] patients were included. The majority were [10-30] years old, and [males]. The incidence of dengue fever was highest during [monsoon season]. The data shows that SGPT/ALT and SGOT/AST value is very high on the dengue positive individuals and total bilirubin value is also high on dengue positive individuals. Conclusion: This study highlights the significant impact of dengue fever on liver function in Kolkata. The findings suggest that early detection and management of dengue-induced hepatic dysfunction are crucial to prevent severe complications. Public health measures should focus on vector control, timely diagnosis, and appropriate treatment to mitigate the burden of dengue fever in Kolkata.

Arab translators dealing with audiovisual products encounter enormous constraints when subtitling English into Arabic. The constraints are massive, representing linguistic and cultural as the bulk of the problematic areas. In contrast, other constraints, such as technical constraints, remain depreciated and have received less notice in research until now. Therefore, this study aims to identify the technical constraints that Arab translators face when subtitling Audiovisual products from English into Arabic. The analysis of previous contributions of some scholars and researchers revealed certain subtitling conventions wherein technical constraints such as the number of lines, characters, and words per line affect the readability and the quality of subtitling. These constraints not only exist but also seem to exist because Arabs desperately need a long overdue revolution in the subtitling industry fueled by state-of-the-art digital technology that would help tackle the technical issues associated with subtitling. The problems are investigated in depth, and solutions to overcome them are explained to enhance Arab translators' technical expertise and knowledge in generating high-quality subtitling.

Introduction: Sports injuries can have long-term psychological and physical ramifications. For instance, concussions can affect a person's quality of life by causing a variety of cognitive problems and emotional swings. Joint injuries can also make athletes more susceptible to musculoskeletal issues in the future, which could limit their capacity to exercise and lower their level of enjoyment and general well-being. Gaining a thorough grasp of the mental health and psychological well-being unique to top athletes may help to improve models of treatment and management for this group, which might ultimately lead to improved performance, lower risk of injuries and improve quality of life. Sport professionals, such as coaches, medical personnel, and sport psychologists, need to have this understanding in order to help elite athletes improve their mental wellness by helping them build coping mechanisms. Methods: The study was performed in NIMS University, in 2024. The survey contained information about the purpose and objectives of the study, informed consent, sociodemographic questions, questions related to mental health, life satisfaction and level of injury questionnaires concerning various aspects of well-being (stress level, depression, anxiety, satisfaction, and physical health, level of physical, mental and social functioning). Result: In this study, a total of 258 participants were included in the analysis. The average age of the participants was 19.5 years, with 52.7% of the sample being women and 47.3% men. Conclusion: A distinct set of pressures that elite athletes face might make them more susceptible to mental illness. Important elements include coping with continuous performance pressure from competition, the psychological effects of injuries, life satisfaction, overtraining, and burnout, and intensive public and media scrutiny.

This study describes the creation and development of the PUERPERIUM software, which utilizes the General Comfort Questionnaire translated into Brazilian Portuguese and adapted for postpartum adolescents. The software development process followed five steps: (1) requirements elicitation, involving the extraction of functionalities and identification of quality attributes such as usability, reliability, security, and availability; (2) definition of the software project and architecture, including the selection of technologies such as programming languages and services; (3) software implementation; (4) validation, verification, and testing; and (5) deployment. The software development began with identifying the necessary requirements, followed by designing the architecture consisting of the server layer and visualization layer. During implementation, the integration of the General Comfort Questionnaire and the selected technology was achieved. Key features such as authentication screens, a patient grid, instrument completion forms, and reporting tools were developed. The software's logo and overall layout were also designed. Subsequent phases involved validating the software’s appearance, usability, and functionality. The complete implementation will include making server layer elements available online and providing a beta version of the visualization layer on a public platform. The software aids nurses in efficiently and systematically assessing the comfort levels of postpartum adolescents, thereby facilitating care aimed at promoting comfort.

In GH deficiency, rhGH is deemed appropriate when epiphyses are open, while Turner's syndrome poses unique considerations due to associated malformations like cardiac aortic bicuspidity and aortic coarctation. Renal malformations, including Horseshoe kidney and hydronephrosis, further highlight the complexity of Turner's syndrome, requiring a comprehensive, multidisciplinary approach to care. We report the case about of an elderly child 3 years and 5 months old patient with cardiac and renal malformations notably a tight postductal isthmic coarctation and a left pyeloureteral junction syndrome with dilatation of the pyelocalic cavities, admitted for further management of a staturo-ponderal delay. She presented with functional signs of constipation, no chills, no digestive disorders and no hypoglycemic malaise. On physical examination, dysmorphic features included low hairline and short neck, pterygium coli, low ear implant, hypertelorism, nipple spread, keloid lesion on face. Test results showed a 45x karyotype in favour of Turner syndrome, HBA1c: 5.6%, the rest of the tests were normal. GH was indicated in the patient after cardiac surgery for coarctation of the aorta and pyelo-caliceal junction. The patient was referred for heart and kidney surgery. It is crucial to closely monitor height velocity during catch-up growth, particularly in patients with concurrent conditions leading to short stature. Additionally, there is an emphasis on educating parents about the potential impact of Turner syndrome on aspects such as growth, growth hormone (GH) substitution, ovarian failure, malformations, and related health risks.

Exophthalmos is typically associated with Graves’ ophthalmopathy. Although originally described by Harvey Cushing, exophthalmos is an underappreciated sign of Cushing’s syndrome. We present a case of a patient aged 40 years with no pathological history presenting with generalized asthenia associated with weight loss of 15kg for 2 months, epigastralgia and incoercible vomiting. Clinical examination revealed a normotensive, normocardiac patient with pain on epigastric palpation, bilateral exophthalmos, and an unremarkable cervical examination No cushingoid syndrome especially no facial erythrosis, no purple stretch marks, no buffalo hump, no amyotrophy of the lower limbs. An abdominal CT scan performed before the abdominal pain revealed an adrenal incidentaloma, a right adrenal nodule, well limited, of low density, homogeneous, very discreetly and homogeneously enhanced after injection of contrast medium, whose hemodynamic behavior was in favor of a benign adenoma. The patient underwent surgery for right adrenalectomy, with morphological and immunohistochemical findings in favour of adrenocortical carcinoma, with clinical and biological improvement. We discuss the possible mechanisms causing exophthalmos in patients with either endogenous or exogenous hypercortisolemia.

Background: Mental health issues, such as stress, anxiety, and depression, are becoming more common among high school students, yet cultural stigma and inadequate mental health literacy impede effective help-seeking in Vietnam. Adolescents sometimes encounter obstacles in identifying mental health issues and obtaining suitable resources, particularly in environments where professional services are inadequate and mental health is stigmatized. Purpose: This study aims to address the comprehension of mental health awareness and help-seeking behaviors among Vietnamese high school students. Methods: The study involved 422 high school students from four cities in Vietnam. The Depression Anxiety Stress Scales (DASS-21) and Mental Health Literacy Scale (MHLS) were employed to evaluate mental health awareness and behavior, with data processed utilizing SPSS version 22.0. Result: Students exhibited the greatest awareness of bipolar disorder (M = 4.43, SD = 0.844). Students experience a moderate to high level of anxiety when they become aware of potential mental health issues (M = 3.50, SD = 1.296). In order of priority, students actively seek information about mental health professionals (M = 3.88, SD = 0.645). Students are highly critical and thoughtful in comparing different sources of advice before deciding on a mental health strategy (M = 4.27, SD = 0.925). Students are slightly more likely to participate in these programs compared to other formal mental health resources (M = 1.44, SD = 0.469). Some students turn to online communities for support and guidance in managing their mental health issues (M = 1.63, SD = 0.483). Conclusion: This investigation underscores numerous critical developments in the mental health awareness and help-seeking behaviors of students in high schools. Students exhibited a deliberate approach to evaluating mental health resources and a strong awareness of bipolar disorder.