In an attempt to synthesize some novel, potent antitubercular and antioxidant agents here we have reported the synthesis of a novel series of tetrahydroquinoline derivatives (III a-g). In this the titled compounds were synthesized by the reaction between substituted aromatic primary amines, N-vinylpyrrolidin-2-one and 4-nitro phthalic acid in acetonitrile. Structure of the synthesized compounds were confirmed on the basis of their physico-chemical and spectral data (IR, 1H NMR, 13C NMR and Mass). All the synthesized compounds were screened for their antitubercular and antioxidant activities using the Microplate Alamar Blue Assay (MABA) method and nitric oxide scavenging, DPPH method respectively. For antitubercular and antioxidant activities screening isoniazid and ascorbic acid were used as the standard drugs respectively. Among the synthesized compounds III a, III d and III e have shown significant anti-tubercular activity and compounds III a, III b and III e have shown significant antioxidant activity

Smartphones have turned out to be a major part of the lives of Nigerians owing to its unique capacity to combine communication and computing on mobile devices. Its evolution has made it an indispensable item in the possession of Nigerians, especially youths and elites of the older generation, as it allows for social interaction, business communication, safe storage of personal files and mobile learning among other things. Through a critical review of relevant academic studies, the article explores the evolution of smartphone in the world and how Nigerians have adopted the device. This paper argues that Nigerians adopt smartphones due to reasons such as educational needs, social communication needs, social influence and brand name and features. Some of the potentials of smartphones to the Nigerian society, as the paper posits are; knowledge sharing in work environment, improvement of social and business relationships, creation of new business dimensions and the availing of health/educational resources. Issues such as addiction, selfie syndrome, social disconnection, academic-related problems as well as health challenges were raised as the negatives from the utility of smartphones. The paper recommends that Nigerians be more disciplined with their phones when in meetings and that students should only use their smartphones to access educational materials outside the examination halls. Also, people should limit their exposure to smart phone screens to avoid visual-related problems.

The pleomorphic adenoma is a benign tumor of the salivary glands. It accounts for 45 to 65% of benign salivary gland tumors. It develops most often in the main salivary glands, especially the parotid, but it can also reach the accessory salivary glands, such as those of the palate or rarely the upper lip. We report a case of pleomorphic adenoma of the upper lip. Patient of 32 years, admitted in our formation for a painless tumefaction of the upper lip, evolving since 6 months. The clinical examination showed a subcutaneous nodule of the superior white lip, of firm consistency, mobile relative to the underlying planes, about 1 cm in diameter. Surgical excision was performed under local anesthesia with a cutaneous approach and removal of the tumor without breaking the capsule. Histological examination revealed a pleomorphic adenoma. Currently there has been no recurrence after three years of decline. The pleomorphic adenoma is a benign tumor of the salivary glands, its preferential localization is the parotid gland, rarely in the accessory salivary glands. The labial localization is very rare. It mainly affects young adult males, often asymptomatic, slow-growing, of firm consistency, well circumscribed in most cases and closer to the mucosa in relation to the skin. Our case has the particularity of being subcutaneous, which posed the differential diagnosis with a tumor of cutaneous origin. The positive diagnosis is based on surgical excision with histological examination. The potential for recurrence is very important, the excision must be complete with a margin of safety avoiding the major capsular intrusion factor risk of recurrence, and prolonged surveillance is required for the search for recurrence or malignant transformation

The adult earthworm Eudrilus eugenia are exposed to four sublethal concentrations such as 0.25gm/Kg, 0.5gm/Kg, 0.75gm/Kg and 1gm/Kg ZnO NPs. Biochemical and tissue damaging parameters are studied in Gut, Bodywall and Testis organs of both control and nanoparticles treated groups. The ANOVA results showed ZnO NPs treated groups results are significantly differed (p<0.05) than control group. Total Sugars, Total Cholesterol, Total Protein levels are significantly reduced whereas increased Urea, transaminase (GOT & GPT) and phosphatase (ALP & ACP) levels found in treated group organs. The results indicated that exposure of ZnO NPs through soil disturbed the basic biochemical compounds in tissues and their damages are indicated by increased enzyme levels.

This study aims to predict the possibility of adopting zero-based budgeting (ZBB) system in Borno State. To ensure this, the study considered viability as predictor variable that was perceived to have contributed to adoption of ZBB in the state. ZBB has resurfaced as a prominent topic of discourse due to the economic downturn experienced in Nigeria as well as the failure of the existing traditional budgeting system to meet the economic objectives of the government. The focal point of discourse, therefore, dwelt on Borno state because it is adversely affected as a result of the revenue volatility witnessed in the country as well as the level of budget implementation with the existing budgeting system in the state experienced decade of monumental budget indiscipline at all levels of government. In view of this, Binary logistic regression was employed to examine whether the predictor variable have significant influence or not on the dependent variable, that is, the adoption of ZBB. Stratified sampling technique was used to arrive at a sample size of 103 drawn from the total population of 139. The findings of the study established that the adoption of ZBB in the state is politically feasible and offers more appealing opportunities in minimizing costs and prioritizing government‘s needs while adding value to the operational efficiency in the budgeting system. It is therefore, pertinent to recommend the establishment of implementation plan that are consistent with synergistic principle and application of ZBB which ensure aggregate fiscal discipline and enhanced technical efficiency through transparency and accountability.

The aim of the present study was to investigate the antibacterial properties of Acalypha indica. Number of resistant antibiotics is increasing and antibacterial activity testing is one of the steps to find treatment of diseases. Acalypha indica is well known medicinal plant and it is a wild plant. It was used as infection treatment for generation to treat several diseases such as asthma, and pneumonia.The susceptibility of five human pathogenic bacterial species to Acalyphin isolated from the leaves of Acalypha indica plant was screened using the agar well diffusion and broth micro-dilution assay. The purity of Acalyphin isolated was checked by TLC and column chromatography and total Acalyphin were quantified. In the present study, the inhibitory action of the Acalyphin was found to increase with an increase in concentration against all bacterial strains. The maximum zone of inhibition was observed at the concentration of 500 µg/ml against all the bacteria. In this study, the S. aureus and E. coli are the more susceptible than the other selected human pathogenic bacteria. From the above investigation the experimental Acalypha indica plant may solve the multidrug resistant bacteria problem and further higher studies is need for qualitative study for the present investigation.

Osteoarthritis (OA) is the most prevalent degenerative joint disease and the most important reason of the physical disability in the elderly population. Along with the fact that OA pathogenesis is not fully known, it is highlighted in the recent studies that oxidative stress is an important factor in OA progression. OA treatment comprises attenuation of pain, maintenance of functional capacity, and development of life quality. Tai Chi Chuan, also known as Tai Chi, is a traditional Chinese martial art and exercise. In recent studies, it has been reported that Tai Chi, as an alternative therapy, can alleviate the symptoms of OA and be effective against oxidative stress.

Six cyanobacterial strains were isolated from pesticide exposed paddy field soil by enrichment method. The isolate exhibited unicellular and filamentous character and are designated and identified as JMCTTKC1-Phormidium pachydermaticum, JMCTTKC3-Oscillatoria chalybea, JMCTTKC4-Oscillatoria tenuis, JMCTTKC5-Oscillatoria ornata, JMCTTKC6-Chroococcus dispersus and JMCTTKC7-Phormidium tenue. The effect of 0.05% of lambdacyhalothrin was analysed on chlorophyll-a and protein content of the cyanobacterial isolates in mineral medium at different time intervals. The maximum level of chlorophyll-a content JMCTTKC4-Oscillatoria tenuis-39.3500µg/mL and protein content JMCTTKC6-Chroococcus dispersus- 99.9µg/mL was recorded on the 9th day sample. At the same time decreased level of chlorophyll-a content JMCTTKC1-Phormidium pachydermaticum-3.8597µg/mL and protein content JMCTTKC3-Oscillatoria chalybea 24.73µg/mL was observed on 13th day sample. From this above observation it was clearly noted that the selected isolates are capable of degrading Lamdacyhalothrin pesticide and used its metabolites as a sole carbon and nitrogen source for their growth.

Hereditary gingival fibromatosis (FGH) is a gingival pathology of genetic origin characterized by a slow and progressive proliferation of the keratinized gingiva. The diagnosis is clinical, confirmed by histology. The treatment is surgical and involves the excision of excess tissue with gingivoplasty, but the recurrence rate remains high, especially in severe cases. We report a case of generalized FGH, whose evolution was favorable after surgical treatment. Observation: A 42-year-old patient, with no notable history, who presented in our consultation for a gingival hypertrophy evolving since childhood. Endobuccal examination showed diffuse gingival hypertrophy with poor oral status. Gingival biopsy revealed gingival fibromatosis. Treatment consisted of excision of excess tissue with gingivoplasty. No recidivism after a decline of three years. Discussion: FGH is a genetic gingival pathology whose clinical appearance is variable, it may be generalized or localized to a maxillary sector, isolated or associated. The positive diagnosis is mostly clinical confirmed by histology (hyperplastic epithelium and dense connective tissue), the treatment is surgical and consists of excision of excess gingival tissue with gingivoplasty. Our patient has a severe FGH that has evolved after surgical treatment

Presently an experiment was conducted so as to understand the moulting behaviour in freshwater crab Maydelliatelphusa masoniana in the laboratory conditions. Out of eight crabs only five could moult while three died during ecdysis. All the crabs exhibited the same pattern of moulting viz., appearance of double lining in pereiopods, the old carapace becoming light in colour follow by its split along the posterolateral margin of the dorsal side, anterolateral border of the ventral side and posterior border of the chelipeds and legs. A new pre-exuvial soft layer is formed below the old carapace. The whole process of moulting got completed within 20-25 minutes.

Staff development is crucial as it equips workers with life long survival skills on their jobs. Staff development also bridges the gap between the teachers’ available acquired skills and the new teaching skills required in the curriculum. Staff development is therefore concerned with the expansion of knowledge and skills of teachers so that they contribute to their growth in relation to their jobs and improve student learning through enhanced performance by the teachers. This study sought to evaluate the effectiveness of school based staff development programmes in Zimbabwean secondary schools using the quantitative paradigm. The study employed the survey descriptive design. The target population comprised all schools in Gweru District using a sample of 220 teachers and heads composed of 112 females and 108 males. All the information was collected using a questionnaire which had both close-ended questions and open-ended questions. The study revealed that lack of follow up evaluation sessions to staff development programmes affect the effectiveness of staff development design and implementation. The study also revealed that time allocated to staff development programmes was not adequate resources. The study recommends that there should be adequate resources to effectively plan and implement staff development programmes and that staff development programmes must be allocated enough time for them to be effectively carried out.

The Murrel fish (Channa striata) is a of freshwater fish species, native to South Asian region and it contains high nutritional values. The murrel fish is a good source of Omega fatty acids and proteins, omega fatty acids and proteins helps to speed up the healing processes. For the present study Murrel Fish is purchased from local market of Aurangabad (MS) India. The fatty acid composition of oil extracted from Murrel fish has been investigated. Fatty acid composition of the oil is determined by Gas Chromatography. It is found that the Murrel Fish is rich in Palmitic acid, Stearic acid, Oleic acid, and Linoleic acid. Arachidonic acid, Behenic acid & Ricinoleic acid are also found in Murrel fish.

The parotid gland lipomas are rare; they are located mainly in the superficial lobe. We report 3 cases of parotid lipomas whose diagnosis was suspected by tomodensitometry and confirmed by histology. Treatment was a superficial parotidectomy for two patients and enucleation for one patient. Parotid lipomas are located mainly in the superficial lobe. The diagnosis is based on imaging, but only histology can confirm. The treatment of superficial lipomas is based on superficial lobe parotidectomy but sometimes enucleation could be enough. In all cases, the recurrence rate is very low

Nowadays, Aquatic pollution has become a global problem. Fishes are sensitive to a wide variety of pesticide chemicals. The effect of Cypermethrin (25% EC) pesticide on behaviour and histopathology of black molly, P. latipinna is studied. The 96hr LC50 concentration is found as 0.035ppm. 1/10th of the concentration 0.0035ppm is used for this study. Decreased swimming activity, excessive secretions of mucous around opercular region are observed in Cypermethrin exposed fishes. The gill histopathological changes observed in at 1st, 4th, 8th, 12th and 16th day of 0.0035ppm exposure exhibited gill lamellae includes less affected and less damages in the gill structures, curling and fusion and shortening of gill lamellae, severe necrosis in primary and secondary gill lamellae, club shaped secondary gill lamellae. Cypermethrin (25% EC) pesticide becomes toxic to the aquatic organisms even in low concentration.

The purpose of present research work was to fabricate patient friendly, immediate release oral film of ondansetron hydrochloride using hydrophilic excipients. The film was prepared by solvent casting method. Hydroxyethyl cellulose, polyvinyl alcohol and polyvinylpyrrolidone k30 along with different plasticizers (peg 400 and pg) were scrutinized for film formulation. The auxiliary excipients used were sodium saccharin and sodium lauryl sulphate. The final selection was done with hydroxyethyl cellulose as a film former and peg 400 as a plasticizer for the film. The drug loaded films of hydroxyethyl cellulose were evaluated for thickness, uniformity in drug content, folding endurance, disintegration time, in-vitro drug release studies, tensile strength and drug-excipient compatibility studies. Taste masking was done by novel sandwich technology (placing the ondansetron hydrochloride film between two listerine pocket pack films). This approach can be used as platform technology for other formulations also. Optimization of film was done by 32 factorial design taking amount of hydroxyethyl cellulose and sodium lauryl sulphate as independent variables, while disintegration time (dt), % cumulative drug release and folding endurance as response variables. Polynomial equations were derived. The validity of equations was checked by preparing check point batches. Response surface plots were constructed using design expert software. This exercise facilitates bio batch selection. Better predictive ability was achieved, when artificial neural network (ann) was used in place of regression analysis. Batch of3 containing hydroxyethyl cellulose showed disintegration time of 16 sec and 94.35 % drug release in 8 minutes.