Tamsulosin HCl is an αq-1 adrenergic receptor antagonist that is primarily used to treat benign prostatic hyperplasia (BPH), a disease defined by an enlarged prostate. The aim of this project is to develop, analyze, and compare the developed formulations to the innovator product (Flomax). The formulations were prepared by integrating Eudragit L100-55 as enteric polymers in various formulations, Drug coat L30D as a sustained release coating polymer, and PEG 6000 as pore forming in distinct quantities. The formulation F8 exhibited %CDR of 98.8%, comparable to the Flomax (innovator product) and the similarity factor (f2) was calculated and found to be 94.3% marking this formulation equivalent to the innovate product. The improved formulation was tested for stability for the 1st month at 40 ± 2°C and 75 ± 5% R_H, as per ICH guidelines. The regression results of the improved formulation led to an inference that F8 indicates first-order kinetics with an estimated regression value of 0.926, and it was concluded that the drug had been released through diffusion mechanism.

Strategic administrative initiatives in schools helps in identifying emerging trends and anticipate future challenges, allowing them to prepare and respond proactively so as to bring change in students’ academic performance. For three consecutive years (2016 -2018), Kisii County’s mean standard score in Kenya Certificate of Secondary Education declined resulting to an average mean standard score of 3.765 (D+) which was still below the National Mean Standard Score of 3.962. The purpose of this study was to determine the extent to which strategic administrative initiatives influence academic performance. Education Production Function theory was applied. The study employed a descriptive survey design. Target population of 353 principals and 4354 teachers were considered from 353 public secondary schools in Kisii County. Slovin’s formula with a margin error of 0.05 was used to sample 28 principals and 341 teachers as respondents. Stratified random sampling was used to get school categories. Instruments for this research included: questionnaire for teachers and interview schedule for principals. Validity of research instruments was ascertained by supervisors’ inputs from the School of Education Kisii University. Questionnaires were considered reliable since Cronbach’s Coefficient Alpha 0.998 obtained was higher than the critical Cronbach alpha of 0.7 on a scale of -1 to +1 by use of test re-test method. Data was analysed both qualitatively and quantitatively. Qualitative data on interview schedules were organized based on research objective and themes of study. Data was presented using percentages, means, frequency distribution tables and bar graphs for easier interpretation. This study’s findings were: The strategic administrative initiatives have a positive influence on academic performance. This study is significant as it indicates that county and sub-county secondary schools need to improve on the application of the strategic administrative initiatives in the academic activities/programs for them to do better academically. In conclusion, National and Extra- County secondary schools’ strategic administrative initiatives have a high positive influence on academic performance compared to county and sub-county secondary schools.

Breast cancer has become the leading cause of cancer-related death among women, partly due to therapeutic resistance and treatment-related complications. Chemotherapy and hormone therapy play a crucial role in managing breast cancer patients, providing essential treatment for both disease control and overall survival. However, as new therapeutic approaches are introduced and life expectancy continues to increase, the use of these treatments has been associated with persistent adverse effects, including dyslipidemia. This article presents the case of a breast cancer patient treated with chemotherapy and tamoxifen-based hormone therapy who developed severe mixed dyslipidemia. It also reviews lipid metabolism alterations observed in breast cancer patients, emphasizing the importance of monitoring lipid levels in these patients, particularly those undergoing hormone therapy or chemotherapy, to prevent cardiovascular complications.

Background: Surgical advancements have led to the development of Enhanced Recovery After Surgery (ERAS) guidelines. This study aims to assess the nurse’s role in improving patient outcomes and healthcare efficiency using ERAS. Methodology: This cross-sectional study was conducted in Aster Sanad Hospital Riyadh, Saudi Arabia. Data were collected using a self-administered questionnaire and from electronic medical records. The study sample was given a self-administered questionnaire. Data were analyzed using the Statistical Package for Social Sciences (SPSS), version 21 (IBM SPSS Statistics, Armonk, NY) to analyze the data. Result: The result shows that there is a significant level of confidence among a notable portion of respondents regarding their understanding of ERAS protocols, there are also areas of uncertainty and variability, indicating the need for targeted interventions to enhance comprehension and implementation. Moreover, there is widespread acknowledgement of the pivotal role of nurses in ERAS implementation, yet significant proportions express reservations about nurses' training, workload constraints, and support from healthcare institutions. Conclusion: Overall, these findings emphasize the multifaceted nature of ERAS implementation, requiring a comprehensive approach that addresses training, communication, workload, and resource allocation to optimize patient outcomes and healthcare efficiency in Cesarean surgery units at Aster Sanad Hospital.

This study investigates the concept and strategic significance of economic corridors, particularly focusing on India’s initiatives in Eurasia, including the International North-South Transport Corridor (INSTC) and Chabahar Port. The primary objective is to analyze how economic corridors serve as instruments for enhancing regional integration, economic growth, and geopolitical influence. Drawing from historical trade routes like the Silk Road, the research explores how modern corridors have evolved into critical drivers of global connectivity. The methodology employed includes a systematic review of academic literature, policy reports, and case studies on various economic corridors, with a particular emphasis on India's projects. The research further evaluates the infrastructure, trade facilitation, investment zones, and institutional cooperation involved in these corridors. The study also assesses social and environmental considerations, alongside an examination of ongoing developments in key Indian initiatives. The findings highlight the potential of economic corridors to significantly improve regional trade and integration, with the INSTC and Chabahar Port offering India strategic advantages in accessing new markets and counterbalancing regional competitors. However, the study also identifies challenges, including infrastructure bottlenecks, geopolitical tensions, and the impact of international sanctions, which may hinder the full realization of these corridors' potential.

This study examined language use of the exogamous families in Southwestern Nigeria in order to find out the language choice in a range of domains (formal and non-formal) and with different speech partners. The theoretical framework adopted for this study is Fishman’s (1972) Domain Analysis. Language use questionnaire was structured and administered to these families. The population of the study included nine hundred (900) respondents drawn from twelve (12) Local Governments of South-western Nigeria and the respondents were strictly from exogamous families. Data collected were analysed using statistical tool. The findings revealed that English language is the most used language among the exogamous marriage families in South-Western Nigeria in both formal and non-formal domains. The study also revealed that the children of all the exogamous marriage families have language socialization as they acquired at least one of the languages spoken by their parents easily, but lack the use of it in everyday dialogue rather they prefer to use English. This is because, they lack balance bilingualism or 'multilingualism. The researchers recommended that comparable research could be conducted on exogamous couples living in both rural and urban communities in order to enrich the knowledge of the sociolinguistic findings and better assessment.

This study analyses the Government's responsibilities in implementing land acquisition in National Strategic Projects. This is qualitative research using a statutory approach, case and conceptual approaches. The primary legal materials resulted from relevant laws and legislation. The legal material collected is analysed prescriptively. The results showed that national strategic projects' land acquisition planning arrangements must be accommodated adequately and comprehensively. There are no land acquisition planning arrangements that accommodate justice, which has encouraged the creation of land acquisition conflicts. Research findings show that the Government's responsibility in acquiring land for National Strategic Projects is weak, and regulatory arrangements are unclear. Government responsibility still needs to be stronger and have strict legal regulations. Legal certainty for economic interests in National Strategic Projects is more dominant. At the same time, the Government has ignored the interests of law and justice for the affected communities.

release of greenhouse gases linked to the manufacture of cement. Geopolymer as a binder for making concrete consists of two (2) main components; (1) the alkaline liquid consisting of sodium or potassium silicate and sodium or potassium hydroxide and (2) source material of geological origin or by-products rich in silica and alumina. The combination proportions utilised in this investigation were formulated utilising Scheffe's (5,2) basic lattice mix design approach with the intent to create the trial mix and the control mix. A total of thirty (30) geopolymers concrete sample mixes were made in the laboratory, with fifteen samples for trial mixes and fifteen mixtures for control mixes. These mixtures were used to appraise the performance of the sawdust ash geopolymer concrete in term of its flexural strength property. The study used sawdust ash as the source material and investigation revealed that subjecting sawdust ash to pyrolysis without oxygen has a notable impact on the pozzolanic characteristics of the constituent. Consequently, this also affects the flexural qualities of the concrete. Furthermore, it has been shown that softwood sawdust exhibits superior pozzolanic properties when compared to hardwood sawdust. The study revealed that the optimum flexural strength of sawdust ash blended geopolymer concrete is 3.3002 MPa and the corresponding mix deign obtained. Computer programs were created using Matlab and used for the optimization and prediction of the flexural strength of sawdust ash based geopolymer concrete.

The study of the apical bases has been relevant in orthodontics for many decades; its study was carried out both on jaw models and on lateral cephalograms. Dentistry today is impossible without three-dimensional studies, which allows you to study an object from any angle and visualize the smallest changes in the anatomical structures of the area under study. The use of cone beam computed tomography to study the apical bases of the jaws makes it possible to study the configuration, size, and position of both the bases themselves and the structures that form them. The parameters we proposed allow us to study the width, length and angle of inclination of the apical base on single CBCT sections. Clinical use of the proposed analysis will contribute to more complete and accurate orthodontic treatment planning.

Background: Anemia is one of the common complication of Chronic Kidney Disease that intensifies in grade and severity as eGFR decline which also increases the risks for cardiovascular mortality. The development of anemia and elevated fibroblast growth factor 23 levels are the earliest changes observed in chronic kidney disease. Objective: This study aims to understand the association of FGF23 levels development of anemia in chronic kidney disease patients prior to renal replacement therapy. Methods: This is an analytical type of cross sectional study carried out among 95 respondent'1ged between 18 and 75 years with CKD stage 1-5 before dialysis, divided into two groups- Group I­ comprised of 68 patients and Group 11- included 27 age and sex matched respondents not having CKD, enrolled from two te1tiary-care hospitals, namely- Sir Salimullah Medical College & Mitford Hospital and National Institute of Kidney Diseases & Urology (NIKDU). Socio-demographic status, disease profile and laboratory findings including serum iron, iron binding capacity, ferritin, transferrin saturation, calcium, phosphorus, intact parathormone, vitamin D, eGFR and FGF-23 levels were studied. Result: Mean age of the respondents was 50.1±10.74 (SD) years, mean estimated glomerular filtration rate was 35.92± 22.61 in group I and 91.66± 14.2 in group II. The mean FGF23 level in group I and II were 85.76± 207.54, 21.99± 12.12 pg/mL respectively, serum iron level was 81.61± 39.24 mcg/dL and 95.0± 32.38 mcg/dL in group I and II respectively, serum ferritin level was 225.59± 2 I 2.5 ng/mL and 157.85± 220.89 ng/ml. TIBC was 312.65± 95.83 mcg/dL and 418.85± 118.25 mcg/dL in group I and II respectively. In Group I and II, iron deficiency was found in 23% and 25%respectively when stratified according to serum ferritin level and 26.5% and 22.22% respectively, when stratified according to serum transferrin saturation level. This difference was significant among the group. Serum iron, ferritin, TIBC and TSAT were significantly associated with serum FGF23 levels. Conclusion: Disrupted iron metabolism and high FGF23 levels is commonly found in chronic kidney disease. Clinical laboratory findings have revealed the relation between FGF23 and anemia in no dialysis chronic kidney disease patients.

Dens invaginatus (DI) is a rare developmental anomaly with an unknown etiology and different complexity. It is classified into three types according to Oehler’s classification 1957 based on the extent of invagination. This case involves an upper lateral tooth demonstrating Dens invaginatus type 2, an open apex, and a separate root sheath and diagnosis of necrotic pulp with symptomatic apical periodontitis. A cone beam computed tomography (CBCT) assessment was conducted prior to nonsurgical root canal treatment, which included apexification with bio ceramic material and internal bleaching to address both healing potential and aesthetics. The procedure was performed under an operating microscope, and a 6-month follow-up was conducted with both clinical and radiographic signs of healing.

The present paper deals with the seasonal abundance and distribution of micro algae in the estuarine habitats of the Gosthani River near Bhimili, Andhra Pradesh, India. Water samples were collected for a period of one year from January 2023 to December 2023. A total of 44 species belongs to four major groups such as Chlorophyceae (12), Cyanophyceae (7), Euglenophyceae (5) and Bacillariophyceae (20) were reported from the estuarine regions of Gosthani River. The density of phytoplankton populations in Gosthani estuary varied seasonally with maximum number of cells per liter (5186) was observed in the month of March and minimum number of cells (789) was recorded in the month of August.

Biological therapy increases the risk of fungal infections in chronic inflammatory rheumatism patients. Objectives: To determine the incidence of fungal infections in spondyloarthritis patients on biotherapy in the Moroccan registry (RBSMR) during 3-year follow-up and to identify associated factors. Methods: Patients' socio-demographic, clinical and para-clinical data were collected. The type of biotherapy used and episodes of fungal infections were determinated. Also, the frequency of corticosteroids and NSAIDs use, disease activity, and various comorbidities before and at the time of fungal infection during the 3 years of follow-up were defined. Regarding fungal infection, the germ and location were specified. Results: Seven spondyloarthritis patients out of 194 had a fungal infection (with 8 episodes). Mean age was 44±17 years, with mean disease duration of 11 years. All these patients had comorbidities before and during the fungal infection. At the time of this, all patients were on TNF alpha inhibitors, specifically, one patient was on Adalimumab but later switched to Etanercept, five were on Etanercept, and one was on Infliximab. No case of systemic fungal infection was noted. In the 8 fungal infection episodes, there were 7 cases of appendages’ involvement and 1 case of vaginal candidiasis. Conclusion: The incidence of fungal infections in patients with spondyloarthritis remains low and seems to be related to disease activity and type of biologics.

The aim of this study was to examine the effect of concurrent training on cardiorespiratory endurance, flexibility and speed on male middle distance runners. The study employed experimental research design. All 26 Awuscod male middle distance runners were taken with EG and CG and divided randomly into two equal groups. Both the (EG= 13) and (CG= 13) had taken PT and POT of 12-minute run test, sit-reach test, and 30 meter acceleration test to assess cardiorespiratory endurance, flexibility and speed respectively.EG participated in additional 10 weeks concurrent interventions. While, the CG continued with their usual training The data collected from the study subject were analyzed using SPSS version 25 software by using descriptive statistics (mean and SD) and inferential statistics (paired t-test and independent t-test) with level of significant 0.05. The results showed concurrent training has significantly improved cardiorespiratory endurance and speed on EG (p<0.05). But no significant difference was observed in flexibility. Furthermore, no more significant differences were found in all of the variables in CG (p>0.05). Based on this finding, it can be concluded that concurrent training has a positive impact on the improvement of cardiorespiratory endurance and speed. Therefore, concurrent training is suggested for middle distance runners to improve physical fitness for athletic performance.

Background: Obstetric fistula remains a significant public health issue in low-resource settings, with high prevalence in countries like Bangladesh. The condition often results from prolonged, obstructed labor, compounded by socio-cultural factors such as early marriage, financial constraints, and lack of access to skilled birth attendants. This study aimed to explore the socio-demographic characteristics and surgical outcomes of women undergoing fistula repair at a private hospital in Dhaka, Bangladesh. Methods: This observational descriptive study included 62 women who underwent obstetric fistula repair between September 2010 and September 2012. Data were collected on socio-demographic characteristics, fistula details, and surgical outcomes through a structured booklet completed at various stages of patient care. Surgical success, complications, and post-operative outcomes were analyzed to identify factors influencing recovery and success rates. Result: The study found that 100% of participants were married at an early age, with significant financial barriers reported by all. A majority (87.10%) had home deliveries attended by unskilled birth attendants. Surgical repair was successful in 88.71% of cases, with a small proportion (11.29%) of unsuccessful repairs. Residual stress incontinence was noted in 4.84% of participants. The mean hospital stay was 17.52 days, with 95.16% of participants requiring continuous catheterization for 7 to 10 days. Conclusion: The high success rate of surgical repairs is promising, but the persistence of socio-cultural barriers and residual complications highlights the need for improved access to maternal healthcare and enhanced post-operative care. Addressing these issues is critical for reducing the burden of obstetric fistula and improving outcomes for affected women.