In most cities in developing countries, dwellers continue facing difficulties in adequately accessing potable water in sufficient quantity for their daily needs. These difficulties are perceived by households each time they fetch drinking water or try to get access to potable water for other household activities. This study aims to assess the problem of potable water supply in the Yaounde III Subdivisions’ neighbourhoods and the coping strategies developed by citizens to meet their needs. To achieve this objective, 300 households were selected and investigated based on purposive and systematic random sampling, particularly in the most densely populated neighbourhoods. We proceeded by identifying the different water supply sources of households for their various needs, and assessing the difficulties encountered in getting water and how they overcome them. Results reveal that in Yaounde III Subdivision only 34.33% of the households are supplied by the Cameroon Water Utilities Corporation (CAMWATER), while 65.67% rely on alternative water supply sources (wells, drillings and springs) without any pre-treatment. Among those connected to CAMWATER network, 46.6% do not have a regular water flow. Results also revealed that water sources were located at reasonable distances (less than 1 kilometre) and that 70% of households take less than 30 minutes to fetch water. Failure in water supply is mainly caused by the insufficient pumping capacity of the existing potable water treatment plants which lead to rationing and shortages, but also to rapid population growth and city extension not followed by the extension of the potable water distribution network. To fill the gap in water supply, it is imperative for public authorities to quickly achieve the project on water supply from the Sanaga River. Also, CAMWATER should extend its distribution network and improve its maintenance system.