Instructive approaches for testing emerging malaria vaccine candidates could potentially have a lot of translational value. The potential of genetically altered Plasmodium species that do not grow beyond the liver stages, in triggering a protective immunity. Giardia-lamblia, Ascaris-lumbricoides, Trichuris-trichiura, Schistosoma species and Entamoeba-histolytica are most intestinal worm parasites around worldwide. Amebiasis is caused by Entamoeba histolytica invading the intestinal mucosa and causing severe mortality and morbidity. Babesiosis is tick borne infectious disease which causes anaemia, fever, haemoglobinuria, and frailty in the animals. Various bacterial species have been found in fish’s natural habitats. Bacterial colonies can be seen on fish’s gills and skin as a result of persistent contact to unclean water, whereas polluted water or food might harm the gastrointestinal tract. Salmonella nontyphoidalis is the most common zoonotic bacterial food borne infection in humans. Salmonellae are common around the world, and they are the most common pathogenic bacteria in both humans and animals. Engineering the genes which code for pathogenicity effectors and host adaptability could be the key to completely identifying the causal relationship among a gene deficiency and infections in organoids.