Introduction: Breast cancer is the most common malignancy in women, accounting for 56% of all female tumors. it is one of the leading causes of death in female. Metaplastic carcinoma is another rare carcinoma, with incidence accounting for 3-6 % of breast carcinoma. Early treatment management has better prognosis. Aim: To detect the importance of immunohistochemistry studies in detecting breast carcinoma. Material and Methods: Among 75 total mastectomy specimens received in Sree Balaji Medical College in department of Pathology 57 cases reported as ductal carcinoma insitu, Metaplastic carcinoma 5 cases, Papillary carcinoma 10 cases and Neuroendocrine carcinoma 3 cases. Among 5 Metaplastic carcinoma cases, Immmunohistochemistry staining was done with tumor marker CD68 and CK to find the expression of the markers in tumor cell and to find rare variants in the carcinoma. Results: Out of 5 cases of metaplastic carcinoma of breast, 3 cases were positive for CD68 and CK. CD68 and CK has a sensitivity of 86% and specificity80% in detecting variants in breast carcinoma. Conclusion: Molecular genetic analysis should be done in breast carcinoma in large number of cases to know the onset of this rare variant and early treatment management gives better prognosis.