Laterite-quarry dust cement block are masonry unit produce by full replacement of natural sand with appropriate mix of laterite and quarry dust. Static modulus of elasticity is an important parameter in predicting the structural behavior in service under load action and determines the deformations and displacements distribution concrete and similar other structural members like blocks. In this work, a mathematical model is formulated using Mixture experiment for predicting the static modulus of elasticity of laterite-quarry dust block. The model is tested for lack of fit and found adequate.