Four samples of Guadua Angustifolia (Colombian Timber Bamboo) bamboo culms were investigated in this study in order to determine the effects of nodes and other physical properties on the compressive strength. The samples were categorized into two groups; samples with nodes (labeled 1M and 1G) and samples between nodes (internode) which were labelled 1J and 1B. The mechanical properties such as moisture content, density, modulus of elasticity and compressive strength of the samples were studied in the laboratory. From the results obtained, it was observed that the density of all the bamboo samples was directly proportional to their respective compressive strengths. Bamboo culm samples from the internode part had a compressive strength that is lower than that of those from the node part (1M and 1G). The culm sample from the node part (1M) had the highest compressive strength of 80.5379 N/mm2 while the culm sample from the internode part (1B) had the lowest compressive strength of 60.8930 N/mm2. The culm diameter, wall thickness and length influenced the cross-sectional area over which the stress was determined. Therefore, the mechanical properties of bamboo are dependent on its physical properties to a reasonable extent.