Pyogenic granuloma (PG) is a widespread tumor-like growth of the oral cavity. This lesion is generally caused by continual poor oral hygiene and low-grade trauma. Many methods have been proposed to remove these lesions. The using of lasers, one of these methods, is considered a safe and effective technique for the removal of these lesions with many clinical advantages such as hemostasis, no intra-operative bleeding and decreased times of healing and pain. The aim of this report is to evaluate the diode laser treatment of three patients with PG. In this case series three uncommon cases of histopathologically PGs in the mandible are presented with the treatment plan of using diode laser to surgically excise the lesions. The patients reported no pain after the surgery. They were discharged with a prescription of chlorhexidine mouthwash and necessary post-operative instructions. The results of this case series demonstrate successful results in the treatment of diode laser pyogenic granuloma-like gingival lesions. The diode laser can be used as an alternative treatment option for the treatment of intraoral PG lesions that minimizes recurrence and increases postoperative comfort and healing.