Background: Glycemic control remains a cornerstone of diabetes management. However, glycemic values are often interpreted in isolation, without sufficient consideration of their daily variability and clinical context. The concept of the glycemic cycle provides a dynamic and patient-centered framework for understanding glycemic fluctuations beyond static measurements. Objective: This review aims to highlight the clinical relevance of the glycemic cycle and to emphasize the importance of its proper interpretation in contemporary diabetes care, particularly in the context of evolving glucose monitoring technologies. Methods: We provide a narrative synthesis of current evidence and international recommendations regarding glycemic cycle monitoring, including capillary blood glucose measurements and continuous glucose monitoring systems. Key aspects addressed include clinical indications, practical implementation, and interpretative principles. Results: Glycemic cycle monitoring enables a comprehensive assessment of daily glycemic variability, complementing glycated hemoglobin in the evaluation of metabolic control. Interpretation of glycemic cycle data requires individualized glycemic targets, an understanding of pharmacological profiles, and the use of standardized metrics such as time in range and glycemic variability. Continuous glucose monitoring further enhances clinical decision-making through dynamic data and trend analysis. Conclusion: Despite rapid technological advances in glucose monitoring, rigorous interpretation of the glycemic cycle remains essential for optimizing diabetes management. Integrating glycemic cycle analysis into routine practice supports personalized therapeutic adjustments, limits therapeutic inertia, and enhances patient engagement, ultimately contributing to safer and more effective diabetes care.