Aim of the study: To study salivary immunoglobulin A and lysozyme levels and their relation to dental caries status in a group of Yemeni asthmatic children. Subjects and methods: One hundred children of both genders were enrolled in this study, aged 6-10 years. The cases were divided into two main groups: fifty asthmatic children and fifty healthy children. Every child was examined for dental caries and assessed according to WHO criteria (1997) using defs for primary teeth and DMFS for permanent teeth. Salivary samples were collected from each child in each group and analyzed for sIgA and lysozyme. The relation between them and dental caries status for primary and permanent teeth was evaluated. Results: Results showed that there was no statistically significant difference between gender distributions of asthmatic and healthy children. In addition, there was no statistically significant difference between the mean sIgA levels of both groups. There was a statistically significant difference between asthmatic and healthy children regarding lysozyme levels. This difference in mean lysozyme levels was higher in asthmatic than healthy children. Asthmatic children showed statistically significant differences regarding defs and DMFS scores, which were lower in asthmatics than healthy children. For asthmatic children, there was a statistically significant positive correlation between defs scores and sIgA levels and a statistically significant negative correlation with lysozyme. In asthmatic children, a statistically significant positive correlation existed between DMFS scores and age and sIgA levels. For healthy children, there was a statistically significant positive correlation between DMFS scores and both age and sIgA levels. Conclusion: In children with allergic asthma the salivary concentrations of sIgA and lysozyme were significantly higher and the defs and DMFS scores were lower than in healthy children.