The integration of professional experience, patient preferences, and the best available evidence has become the cornerstone of evidence-based practice (EBP), which has been widely accepted in the field of healthcare. This review looks at the value of EBP, adoption tactics, implementation obstacles, and how it affects patient outcomes in different hospital settings. This review highlights the significance of EBP in enhancing healthcare quality, patient satisfaction, and cost-effectiveness through an examination of recent literature. It also covers the obstacles to implementing EBP and provides advice on how to get beyond them.