Liver illnesses that run in families might start childhood with cholestatic jaundice and proceed to severe hepatic dysfunction. Although congenital cytomegalovirus (cCMV) infection can initially affect the liver in otherwise healthy hosts, chronic hepatitis is rare. We present an infant with cholestatic jaudnice evolving since birth and dysmorphic facies revealing alagille syndrome, the biological tests is revealing a biological cholestasis and a CMV serology positive. The patient was treated for 3 months.