Background: Primary healthcare services are vital components of the global public healthcare system, ensuring access to essential medical services, preventive care, and addressing various health needs. This study focuses on the challenges faced by residents of the Najran Region in accessing and utilizing primary healthcare services in Saudi Arabia. Aim: The aim of this investigation is to shed light on the barriers that residents in the Najran Region face when it comes to accessing and utilizing primary healthcare services and to emphasize the need for targeted interventions to enhance the primary healthcare system. Methods: A mixed-methods research approach, incorporating quantitative surveys and qualitative interviews, was employed to assess the accessibility and utilization of primary healthcare services in the Najran Region. The study examined factors such as geographical accessibility, socio-economic determinants, and healthcare-seeking behaviors. Results: The study found several challenges in accessing and utilizing primary healthcare services in the Najran Region. These challenges are influenced by geographical accessibility, socio-economic determinants, and healthcare-seeking behaviors. The results highlight the need for targeted strategies to improve service accessibility and utilization. Conclusion: The accessibility and utilization of primary healthcare services in the Najran Region, Saudi Arabia, are critical areas that require attention. Strengthening the primary healthcare system is essential to address the identified challenges and improve healthcare outcomes.