Objectives: Nurses’ professional values have an important role in shaping nurses’ identities. They have an effect by tailoring the care provided and informing the unit’s productivity. Values have the capacity to take patient care to another level, thereby improving the patients’ experience. Likewise, values also influence nurses’ commitment to their organisation, which is considered vital for organisational success. The aim of this study is to examine nurses’ professional values as predictors of their organisational commitment to the Saudi Ministry of Health (MOH). Methods: A cross- sectional descriptive correlational design was selected for this study, which was conducted in two major hospitals in Jeddah. The study’s participants were recruited using a convenience sampling technique. The total sample comprises 412 staff nurses. Results: The results show that nurses have strong professional values and high levels of organisational commitment. Almost all the professional values domains correlate with the organisational commitment domains. This study asserts that professional values are a predictor of organisational commitment. Conclusion: Nurses’ professional values and organisational commitment both have an impact on nursing care, behaviour, and organisational outcomes. Therefore, an understanding of the relationship between these two concepts can improve nursing practices.