Background: Hypertension, Known as an increase in the blood pressure, the blood vessels have raised pressure. Hypertension is a big universal health problem affecting one in three adults, and its mortality rate is 1,000 deaths per day. According to the World Health Organization, more than 80% of deaths from hypertension and related cardiovascular diseases currently arise in low and middle-income countries and are predominately common among persons of low socio-economic status. Risk factors of hypertension are not well studied in adults, and public awareness of hypertension in countries undergoing epidemiological transition is dismal. High blood pressure is one of the most important modifiable risk factors for stroke, with the risk of stroke increasing continuously with increasing levels of blood pressure [1]. Objective: The aim was to assess nurses' knowledge regarding risk factors of hypertension at Shaheed Ziaur Rahman Medical College Hospital, Bogura, Bangladesh. Methodology: This descriptive cross-sectional study design was used, and a sample size of 110 that was a purposive sampling technique followed those who met the inclusion criteria to assess the nurse's knowledge regarding risk factors of hypertension. The study was conducted from July 2021 to December 2021. The instruments for data collection were a semi-structured questionnaire composed of two parts: Demographic variables and knowledge-based information on risk factors of hypertension. Results: The findings of the present study revealed that the demographic characteristics of the highest 52.73% were within 31-40 years; 77.22% were female; 89.09% were Islam; 83.64% were married; 46.36% were diploma in nursing and average knowledge score 42% were the moderate level of knowledge regarding the risk factors of hypertension. Conclusion: Hypertension is an important health problem in both urban and rural areas of Bangladesh. The emergence of hypertension and other cardiovascular diseases is strongly related to various risk factors. The finding of the present study was that the level of knowledge about the risk factors of hypertension was 42% moderate level of individuals.