This synthesis of research was carried out in order to assess the impact of chemical treatments on gum tissues. Chemical compounds are used in a variety of dental applications, including caries prevention, pulp treatment, and periodontal care. Understanding how these medications affect the surrounding tissues is critical for successful treatment results. We thoroughly reviewed the existing literature and relied on any relevant research published between 2000 and 2021. The results imply that, depending on the kind of therapy and the substance used, chemical therapies may have both helpful and negative effects on the tissues around a tooth. More study is needed to determine the most effective techniques for protecting the long-term health of the surrounding tissues.