Numb chin syndrome is a rare presentation due to injury to mental nerve characterized by numbness, hypoesthesia, and paresthesia. This syndrome is mostly presented with dental interventions, traumatic injuries, or malignant pathologies. We report a unique case of a 20-year-old male diagnosed with sickle cell disease presented with loss of sensation over right chin area secondary to the vaso-occlusive crisis. This case depicts a complex relationship between neurological complications and hemoglobinopathies of SCD.