The roles of sex hormones have been under the scope of study for so long by physiologists as well as clinicians. Their actions on the cardiovascular system are undeniable and evidence is growing. Many research investigated the connection between the levels and the protective mechanisms on CVS physiology. It is a popular belief among clinicians that estrogens are powerful protectors of cardiovascular events; but, the notion that testosterone is as well was a novel concept. Testosterone was associated for the longest time with the bad and negative effects on the CVS, such as, increasing the risk for cardiac hypertrophy.