Rosuvastatin calcium is hypolipidemic drug and has low oral bioavailability of about 20% due to poor aqueous solubility and hepatic first-pass metabolism. These are major boundaries inefficient delivery of RC by oral route. Several delivery approaches are known to moderate the difficulties of solubility and increase the oral bioavailability of RC. Among numerous approaches, nanotechnology-based delivery of RC has prospective to overcome the challenges associated with the oral administration. This review focuses on various nano-based delivery systems such as nanoparticles, lipid nanoparticles, SEDDS and SNEDDS and tried for improving the aqueous solubility, dissolution and subsequently bioavailability of RC upon oral administration. Of all, solid lipid nanoparticles appear to be promising delivery system, based on current reported results, for delivery of RC, as this system improved the oral bioavailability and possessed prolonged pharmacodynamic effect.