Information Science is an important interdisciplinary domain responsible for collection, selection, processing, organization and management of information. Information Science is dedicated to information infrastructure building, designing and development. Information Science is an Applied Science domain through it has some community interaction and community development perspective. Information Science has an interaction with its stakeholders like people, industry and corporates. Information Science is as an interdisciplinary domain available in western countries. This paper is talks about Information Science and Information Science and Technology and their possible and probable curriculum differences. Paper also tries to illustrate some proposed courses of MSc-IST.