Objective: To investigate the sensitivity, specificity and diagnostic accuracy of contrast-enhanced computed tomography (CECT) and contrast-enhanced ultrasound (CEUS) for hepatocellular carcinoma (HCC). Methods: The clinical data of patients who underwent hepatectomy in the first Affiliated Hospital of Guangxi Medical University and underwent CECT and CEUS before surgery were retrospectively analyzed. The gold standard was postoperative pathological examination results. Results: A total of 554 patients were included, and 650 lesions were found. The sensitivity and coincidence rate of CECT and CEUS for lesions were more than 94% and 83%, respectively. 14 lesions with diameter less than 2cm which were detected by CUES were not detected by CT and 26 such lesions which were detected by CT were not detected by CUES. Conclusion: CUES and CECT have similar high sensitivity and diagnostic accuracy for HCC. Combined CT and CUES detection could find more small lesions in the liver.