The aim of the study was to formulate herbal soap for the treatment acne and dry skin and statistical optimization of herbal ingredients by 22 factorial design approach. Totally six soap were developed with varying concentration of herbals for preliminary trial. The prepared products are evaluated for pH, foam stability, antimicrobial activities, foam height, moisture content, foam retention time, percentage free alkali, alcohol insoluble content, washing capability etc were also measured. The best preliminary trial soap formulation (F 6) was subjected for optimization by 22 factorial design approach. The study result suggest increasing the concentration of neem extract exhibit improved antibacterial activity. When the concentration of SLS increased, increases foam retention time. The In conclusion the optimized formulation (R4) suitable for effective treatment of acne and dry skin.