Scrap cytology is emerging technique for diagnosing oral lesion. Oral cancer results from various viral infections, oral leukoplakia, and submucosal fibrosis. Scrap cytology assist in identifying these malignant and premalignant lesions. Herein, we present a case of a 70 years old male with complaint of pain and multiple ulceration in right oral mucosa. After proper intraoral examination & scrap cytology smears and microbiological investigations diagnosis of HSV cytopathic effect was given. This case report expands the morphologic spectrum of premalignant oral lesions and emphasizes the need to consider scrap cytology as a useful tool for oral lesions.