Poor sterilizing is led to transfer of so many human diseases such as dysentery, cholera, hepatitis A and cholera. In this review, the important of sanitization to the human diseases is explained and the dynamical relationship between them is illustrated. Sterilizing and hygiene are very important to defeat diseases by washing hands and using alcohol sanitizer to clean floor, stairs offices and indoors. In addition, many types of sterilizers that used to clean are introduced with their components. The risk of using alcohol a lot is discussed also it is compared with normal washing with soaps and non-alcohol materials use. Moreover, the important relation between sterilizing and recent disease such as MARS and Covid-19 is covered in details. Eventually, the antimicrobial resistance that produced from the overuse of the sanitizers is discussed with the aim of covid-19 pandemic.