Many individuals are exposed to bacteria especially those who are raising pets. This interaction between household pets such as cats and dogs and human gives the chance for bacteria to transmit easily. Thereby, these bacteria could transfer from pet’s food and scratching to the owners. In this review, a bacteria gene transmission between pets and human is introduced and discussed. This transmission is happened due to the raising and owning these small animals. In addition, studies on Zoonotic diseases transfer between humans and animals especially pets are presented. Furthermore, the risk of pet ownership by people is reviewed and how should they interact with each other. Also, researches on how Antimicrobial-resistant pathogenic bacteria transmitting between human and pets are discussed. Eventually, gene transfer types between human and pet are explained with their consequences.