Background and Objectives: The rates of Cardiac implantable electronic device (CIED) infections are increasing worldwide due to the increased use of these devices. (CIED) infection is a serious complication that is associated with increased mortality, morbidity and healthcare costs. There is a need to investigate data on the microbiology of CIED infections since it is poorly documented in Saudi Arabia. We aimed to determine microbiological findings of CIED infections in our region. Methods and Results: The study was carried out in cardiology departments at different centers in Saudi Arabia. Our population consisted of all patients with device-related infections over a period of eleven years from January 2009 to December 2020. It was resulting in 137 patients with device infection. Blood cultures and device material swabs were obtained. Staphylococcus aureus was the most common isolated pathogen (37.2%). particularly, coagulase-negative Staphylococcus aureus in 15.3% of cases, Methicillin-susceptible Staphylococcus aureus (MSSA) in 13.9% of cases and Methicillin-resistant Staphylococcus aureus (MRSA) in 8% of cases. Brucella accounted for 9.5% of cases. Negative cultures of CIED infections seemed to be a critical issue over the studied years. Conclusion: Staphylococcus aureus was the most frequently isolated pathogen and Brucella is a considerable pathogen for CIED infections in our country.