In today’s healthcare system, informatics has become an essential part of the infrastructure to improve access to health information, make patient care safer, decrease health care costs, and improve outcomes. The evaluation of these services is an important component of these programs and health professionals should have the requisite knowledge, confidence, and skills to evaluate the impact of the services they provide. However, Nursing staff are seldom adequately prepared by their training or work experience to do this well. In this article the researchers provide a suitable framework and guidance to enable nursing staff to appropriately undertake useful program evaluation. We introduced and discussed Program Evaluation and provided guidelines for its implementation. The framework presented distinguishes program evaluation from research and encourages nursing staff to apply an evaluative judgment, in order that value the merit, worth, and significance of programs can be made. Examples from our evaluation practice are drawn on to illustrate how program evaluation can be used across the Nursing care scope.