HIV infection is known to be a factor associated with cardiovascular disease. The objective of this work is to draw the attention of clinicians working in a resource-limited environment to the risk run by these patients in hospitalization in order to be able to prevent and ensure early and adequate management allowing the reduction of thrombotic risk andits complications. This is a descriptive cross-sectional study from January 2022 to May 2023, all patients hospitalized for advanced HIV disease were assessed by the Padua score supported by the D-dimer test. The data was collected in strict confidentiality. Out of a total of 400 hospitalized patients 40 were identified as being at being at risk of developing venous thromboembolic disease (VTE). The average age was 33, 6 years, 28 patients were female (70%).Coma (37,5%) and dyspnea(30%) were the main reasons for consultation. Cellular immunosuppression was severe (CD4∠200 mm3) in 95% of patients disseminated tuberculosis(50%), pneumocystosis carini pneumonia(25%), sepsis(12,5%), neuromeningeal cryptococcosis(7,5%) and Kaposi’s sarcoma (5%) were the main associated opportunistic conditions. 28(70%) patients were naïve to antiretrovirals and 12(30%) had been on retroviral treatment for six months. 12(30%) patients died, 8(20%) patients progressed well, and 20(50%) were lost sight of for lack financed mean.