Background: It is well known that education and learning can be linked with lucid, playful and pleasurable experiences. Aim: This study evaluated the knowledge, attitude and practice of edutainment among anatomy educators. Methods: The study was conducted among Anatomy educators in four Colleges of Medicine in South Eastern Nigeria. The study adopted a survey research design with a validated structured questionnaire. A total of 34 lecturers (8 females and 24 males) participated in the study. Results: Thirty one (91.2%) of our respondents has heard of edutainment. Their major source of information was from the internet (n=19; 61.3%) followed by conferences (n=9; 29%). Our respondents showed a positive attitude to edutainment. 28 (82.4%) of our respondents said edutainment is not part of their curriculum and 24 (70.6%) of our respondents use edutainment to teach anatomy. Conclusion: Edutainment in anatomy teaching is necessary and will be productive, there is need to complement traditional teaching method (lectures) with edutainment in anatomy teaching in other to increase students’ interest and understanding.