Darvyadi Ghrita is a polyherbal formulation and is mainly indicated for the diarrhoea. It is mentioned in Charak Samhita by Acharya Charak. Preparation of oleaginous dosage form is described as Sneha Kalpana performed by subjecting Ghrita or oil to a particular pattern of heat treated with Kalka (Paste) of Kutaja, Daruharidra, Pippali, Shunthi, Katuka, Draksha and Kwath (Decoction) of same ingredients. Murchana is a pre procedure to Sneha Kalpana in which Ghrita is treated with few drugs. The main ingredients of Darvyadi Ghrita is Kutaja (Holarrhena Antidysentrica Wall.), Daruharidra (Berberis Aristata DC.), Pippali (Piper Longum Linn.), Shunthi (Zingiber Officinale Rosc.), Katuka (Picrorhiza kurroa Royle ex.Benth), Draksha (Vitis Vinifera Linn.) and Go-Ghrita. In Ayurvedic therapeutics the Pharmacokinetics and Pharmacodynamics of the drug entirely depends upon Rasa, Virya, Vipaka, Prabhava and balance of Tridosha in the body. The ingredients of Darvyadi Ghrita with their Rasapanchaka, are very much competent to exhibit anti-bacterial and anti-diarrheal property from Ayurvedic perspective.