Fabrication high performance reverse osmosis (RO) membrane at low cost is necessary in desalination industry. In this paper, we report the use of clay nanoparticles (NPs) to improve RO thin film composite (TFC) membrane. Different concentrations of NPs were embedded into polyamide (PA) active layer of TFC membrane through interfacial polymerization (IP). Results indicated that the membrane impregnated with clay NPs exhibited higher water flux and fouling resistant than the pristine one, and maintained good salt rejection.