Background: Papulo-squamous lesions of skin include a heterogeneous group of disorders, often showing overlap in morphology and distribution of lesions, leading to difficulty in diagnosis. Distinct histopathological features and clinical correlation provides a definite diagnosis in these lesions. Aim/Objectives: To evaluate the spectrum of non-infectious erythematous papulo-squamous skin lesions from North West India. Material and Methods: This retrospective diagnostic analytical study was carried out in the Department of Pathology in a tertiary care centre in North-West India. Skin punch biopsies of clinically diagnosed non-infectious, erythematous papulo-squamous skin disorders were included. Diagnosis was confirmed on histopathological examination. Clinical & histopathological diagnosis of each patient was prepared & correlation performed. Results: Majority of patients were seen in 4th decade with a male predominance. Lichen Planus was the commonest histopathological lesion (42.9%) followed by psoriasis (22.9%). 5 cases of seborrheic dermatitis, 3 cases of pityriasis rosea and 2 cases each of prurigo nodularis and lichen planus pigmentosus were also seen. Clinico-histopathological concordance was observed in 77.1 % cases. Conclusions: Lichen Planus was the commonest papulo-squamous lesion observed in our study. Key histopathological findings and clinico-pathological correlation provides a conclusive diagnosis. Specific histomorphological diagnosis is paramount in distinguishing these lesions as the treatment and prognosis varies widely.