Background: Medical waste is a source of generation of hazardous biomedical waste and its generation and disposal is an important aspect. With the rapid rise in the number of confirmed cases, the amount of COVID-19 related medical waste also increased significantly. Aim: To assess knowledge, attitude, and practice of nurses toward covid-19 related medical waste management, in hospitals of Arar, Northern Saudi Arabia. Method: This was a descriptive cross- sectional study. A pilot study was carried out on a sample of 10% of sample to test the feasibility of the study and clarity and applicability of the tool. A constructed questionnaire was used to collect the data .The collected data was analyzed using statistical package for social studies (SPSS) version 20. Result: Most (86.2%) of the participants had guidelines in hospital regarding medical waste during the Covid-19 period. More than third (35.2%) had a high Knowledge rate of hospital waste disposal (5th levels), 30.3% had 4th level, 24.8% had 3rd level of knowledge rate of hospital waste disposal. Regarding the attitude of participants toward hospital waste disposal during covid-19 outbreak, 71.0%strongly agree and 22.8% agree that gloves are necessary for handling medical wastes, 69.0% strongly agree 23.4% agree that wearing PPE decreases the risk of contracting infection at the hospital. There was a significant relation between years of experience and frequency of separation of medical waste from general waste, cleaning the spills of liquid Medical waste immediately with proper procedure and sorting the medical waste during collection. Conclusions: Most of the hospital had guidelines regarding medical waste disposal during the Covid-19 period. Nurses have a good level of knowledge, a good attitude, a good practice regarding the medical waste disposal during the Covid-19 period.